Sialoadhesin and related cellular recognition molecules of the immunoglobulin superfamily
Sialoadhesin and related cellular recognition molecules of the immunoglobulin superfamily
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DOI：
10.1042/bst0240150
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发表时间：
1996-02-01
影响因子：
3.9
通讯作者：
Mucklow, S
中科院分区：
文献类型：
--
作者：
Crocker, PR;Kelm, S;Mucklow, S
细胞间的相互作用在包括细胞迁移和分化、炎症、免疫功能、发育和胚胎发育在内的广泛的生物和病理过程中发挥着至关重要的作用。根据其一级结构和结构域组织，大多数细胞相互作用分子属于离散的家族。这些包括免疫球蛋白超家族、整合素、钙粘附素和选择素。这些家族中最大的是免疫球蛋白超家族(IgSF)，有100多个成员。这些蛋白质通常被认为通过特定的蛋白质-蛋白质相互作用来调节细胞间的通讯。然而，最近对IgSF[1，2]凝集素样细胞黏附分子唾液酸粘附素家族的表征表明，蛋白质-碳水化合物的相互作用也是重要的。该家族的所有成员都能介导唾液酸(SIA)依赖的黏附。到目前为止，它包括由巨噬细胞亚群[3]唯一表达的同名成员唾液粘附素(SN)，由粒单核细胞[2，4]细胞表达的CD33，由B淋巴细胞[5，6]表达的CD22，由髓鞘胶质细胞表达的髓鞘相关糖蛋白(MAG)[1，7]，以及由鸡和鹌鹑的神经胶质细胞表达的雪旺细胞髓鞘蛋白(SMP)[8，9]。本文将不再进一步讨论SMP，因为它是该家族中最不具特征的，而且到目前为止还没有发现哺乳动物的同源物。唾液粘附素家族的所有成员都有一种SIMI-
Cell-cell interactions play a crucial role in a broad range of biological and pathological processes encompassing cell migration and differentiation, inflammation, immune function, development and embryogenesis. The majority of cell interaction molecules fall into discrete families based on their primary structure and domain organization. These include the immunoglobulin superfamily, integrins, cadherins and selectins. The largest of these families is the immunoglobulin superfamily (IgSF) which contains over 100 members. These proteins are generally considered to mediate intercellular communication through specific protein-protein interactions. However, the recent characterization of the sialoadhesin family of lectin-like cell adhesion molecules of the IgSF [1, 2] has shown that protein-carbohydrate interactions are also important. All members of this family can mediate sialic acid (sia)-dependent adhesion. To date, it includes the eponymous member, sialoadhesin (Sn), expressed uniquely by subpopulations of macrophages [3], CD33 expressed by cells of the myelomonocytic lineage [2, 4], CD22 expressed by B-lymphocytes [5, 6], the myelin associated glycoprotein (MAG) expressed by myelinating glial cells [1, 7] and the Schwann cell myelin protein (SMP) expressed by glial cells of the chick and quail [8, 9]. SMP will not be considered further in this article because it is the least characterized of the family and as yet no mammalian homologue has been identified. All members of the sialoadhesin family have a simi-