Effective ablation therapy of adenomyosis with ultrasound-guided high-intensity focused ultrasound
Effective ablation therapy of adenomyosis with ultrasound-guided high-intensity focused ultrasound
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DOI：
10.1016/j.ijgo.2013.08.022
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发表时间：
2014-03-01
影响因子：
3.8
通讯作者：
Zhang, Lian
中科院分区：
文献类型：
--
作者：
Zhang, Xin;Li, Kequan;Zhang, Lian
目的：探讨超声引导下高强度聚焦超声（HIFU）治疗子宫腺肌病的疗效。研究方法：在一项回顾性分析中，回顾了2010年11月至2012年6月期间在中国四川省遂宁市中心医院接受超声引导HIFU治疗的202名子宫腺肌病患者的数据。在这些患者中，分别有120和82例被归类为局灶性子宫腺肌病和弥漫性子宫腺肌病。所有患者均接受治疗前和治疗后的磁共振成像的标准化协议，以评估治疗。记录所有不良反应。结果：所有患者均在1次超声引导下完成HIFU治疗。实现了71.6% +/-19.1%的非灌注体积比。与治疗前相比，超声引导下HIFU治疗后患者月经过多严重程度评分和痛经严重程度疼痛评分均显著降低（均P < 0.001）。随访3个月时，局灶性子宫腺肌病患者痛经完全缓解的比例明显高于弥漫性子宫腺肌病患者（P = 0.02）。2个患者组之间未观察到其他显著差异。结论：超声引导下的高强度聚焦超声被认为是治疗局灶性和弥漫性子宫腺肌病病变的有效技术，以减轻月经过多或痛经的症状。(C)2013年国际妇产科联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To evaluate the effects of ultrasound-guided high-intensity focused ultrasound (HIFU) on adenomyosis. Methods: In a retrospective analysis, data were reviewed from 202 patients with adenomyosis who underwent ultrasound-guided HIFU between November 2010 and June 2012 at Suining Central Hospital, Sichuan, China. Among these patients, 120 and 82 were classified as having focal adenomyosis and diffuse adenomyosis, respectively. All patients underwent pre-treatment and post-treatment magnetic resonance imaging by a standardized protocol to evaluate the treatment. All adverse effects were recorded. Results: All patients completed the ultrasound-guided HIFU treatment in 1 session. A non-perfused volume ratio of 71.6% +/- 19.1% was achieved. Compared with baseline data, the average menorrhagia severity score and the average dysmenorrhea severity pain score decreased significantly after ultrasound-guided HIFU (both P < 0.001). The proportion of women with complete relief of dysmenorrhea at the 3-month follow-up was significantly higher among women with focal adenomyosis than among those with diffuse adenomyosis (P = 0.02). No other significant differences were observed between the 2 patient groups. Conclusion: Ultrasound-guided HIFU was found to be an effective technique for treating both focal and diffuse adenomyotic lesions to alleviate the symptoms of menorrhagia or dysmenorrhea. (C) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.