Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants
Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants
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DOI：
10.1016/j.jpeds.2005.11.027
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发表时间：
2006-05-01
影响因子：
5.1
通讯作者：
Sedin, Gunnar
中科院分区：
文献类型：
--
作者：
Agren, Johan;Sjors, Gunnar;Sedin, Gunnar
目的为了检验这一假设，相对湿度（RH）的水平，早产儿的护理可能会影响他们的出生后shin matching.Study设计在22早产儿（GA 23-27周），经皮水分流失（TEWL）测定在出生后的年龄（PNA）的0，3，7，14，和28天。在PNA的7天，婴儿被随机照顾在50%或75%RH。结果TEWL下降速度较慢的婴儿在较高的RH（22 +/- 2 g/m2）h）在PNA的28天。在75%RH环境下喂养的婴儿TEWL（22 +/- 2 g/m2 h）比在50%RH环境下喂养的婴儿（13 +/- 1 g/m2 h; P <0.001）大约高两倍。结论结果表明，RH水平影响皮肤屏障的发育，在较低RH环境下喂养的婴儿屏障形成更快。这一发现对促进极早产儿胫骨屏障完整性的策略产生了影响。
Objectives To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal shin maturation.Study design In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH.Results TEWL decreased at a slower rate in infants nursed at the higher RH (22 +/- 2 g/m(2) h) At a PNA of 28 days. TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m(2) h) than in those nursed at 50% RH (13 +/- 1 g/m(2) h; P < .001).Conclusions The results indicate that the level of RH influences skin barrier development, with more rapid harrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting shin barrier integrity in extremely preterm infants.