The relationship between Agent Orange and prostate specific antigen: a comparison of a hotspot and a non-sprayed area in Vietnam.
The relationship between Agent Orange and prostate specific antigen: a comparison of a hotspot and a non-sprayed area in Vietnam.
复制标题
橙剂与前列腺特异性抗原的关系：越南热点地区与非喷洒地区的比较。
DOI：
10.1007/s12199-013-0330-1
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发表时间：
2013
影响因子：
4.7
通讯作者：
Xianliang Sun
中科院分区：
文献类型：
--
作者：
Chikako Shimokawa;Mamum Kabir;Mami Taniuchi;Dinesh Mondal;Seiki Kobayashi;Ibne Karim M. Ali;Masachika Senba;Eric Hoput;Haque Rashidul;William A. Petri Jr.;Shinjiro Hamano;Xianliang Sun
ObjectivesThe aim of this study was to explore the impact of Agent Orange exposure for prostate cancer with a comparison of the prostate specific antigen (PSA) levels between a hotspot and a non-sprayed area.MethodsThe study was conducted in Phu Cat district (hotspot) and Kim Bang district (non-sprayed), with a total of 101 men in the hotspot and 97 men in the non-sprayed area older than 50 years of age. About 5 mL of whole blood and a health status questionnaire were collected from each subject in August 2009–2011.ResultsThe mean age of the subjects in the hotspot (68.0 years old) was significantly higher than that of those in the non-sprayed area (65.0 years old). No significant difference was found between the hotspot area (0.93 ng/mL) and the non-sprayed area (0.95 ng/mL) in terms of PSA levels. Likewise, this was not statistically significant after adjusting for age. The prevalence of high PSA levels (>3 ng/mL) did not differ significantly between the hotspot (14 men; 13.9 %) and non-sprayed area (9 men; 9.3 %). No significant difference was found between the hotspot area and the non-sprayed area in terms of occupation (farmer and others). In control subjects, no significant difference was found between the PSA levels in subjects exposed to Agent Orange and non-exposed subjects. Likewise, no significant difference was found between the PSA levels of combatants and civilians.ConclusionThe PSA levels were not significantly different between the hotspot and the non-sprayed area.
