Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae
Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae
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DOI：
10.1016/j.virol.2008.05.020
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发表时间：
2008-08-15
期刊：
影响因子：
3.7
通讯作者：
Van Ranst, Marc
中科院分区：
文献类型：
--
作者：
Rector, Annabel;Stevens, Hans;Van Ranst, Marc
新的海豚（Tursiops truncatus）乳头瘤病毒序列，TtPV 1，-2和-3的系统发育分析表明，其基因组的早期和晚期蛋白质编码区在进化历史上不同。滑动窗口bootscan分析表明，TtPV 1和TtPV 3的系统发育聚类发生了显著变化，TtPV 1和TtPV 3的聚类顺序从早期与棘鳍海蛇Phocoena spinipinnis PsPV 1聚类到晚期与TtPV 2聚类。这为E2结束/L2开始附近的可能重组事件提供了指示。第二个可能的重组位点可以位于L1末端附近，在上游调控区。选择分析，通过使用最大似然模型的密码子取代排除了强烈的选择压力的可能性，不对称地作用于病毒基因组，作为一种替代的解释，观察到的差异，这些鲸类乳头瘤病毒的早期和晚期基因组区域之间的进化历史。(c)2008年爱思唯尔公司All rights reserved.
Phylogenetic analysis of novel dolphin (Tursiops truncatus) papillomavirus sequences, TtPV1, -2, and -3, indicates that the early and late protein coding regions of their genomes differ in evolutionary history. Sliding window bootscan analysis showed a significant a change in phylogenetic clustering, in which the grouped sequences of TtPV1 and -3 move from a cluster with the Phocoena spinipinnis PsPV1 in the early region to a cluster with TtPV2 in the late region. This provides indications for a possible recombination event near the end of E2/beginning of L2. A second possible recombination site could be located near the end of L1, in the upstream regulatory region. Selection analysis by using maximum likelihood models of codon substitutions ruled out the possibility of intense selective pressure, acting asymmetrically on the viral genomes, as an alternative explanation for the observed difference in evolutionary history between the early and late genomic regions of these cetacean papillomaviruses. (c) 2008 Elsevier Inc. All rights reserved.