Detection of microscopic anisotropy in gray matter and in a novel tissue phantom using double Pulsed Gradient Spin Echo MR
Detection of microscopic anisotropy in gray matter and in a novel tissue phantom using double Pulsed Gradient Spin Echo MR
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DOI：
10.1016/j.jmr.2007.07.003
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发表时间：
2007-11-01
影响因子：
2.2
通讯作者：
Basser, P. J.
中科院分区：
文献类型：
--
作者：
Komlosh, M. E.;Horkay, F.;Basser, P. J.
双脉冲梯度自旋回波 (d-PGSE) MR 实验用于测量和评估大脑灰质以及由随机定向的充满水的管组成的新型“灰质”模型中的局部扩散各向异性程度。在这两个样本中，在宏观尺度上观察到各向同性扩散，而在微观尺度上观察到各向异性扩散，然而，所得到的回声衰减曲线的性质有质的不同。灰质包含多种细胞类型和纤维，表现出比体模更复杂的回声衰减曲线。由于在低 q 状态下观察到的两个样品的微观各向异性与临床扫描仪中可实现的相当，因此它可能为表征医学和生物应用中的灰质微观结构提供新的潜在对比机制。 (C) 2007 年，爱思唯尔公司出版。
A double Pulsed Gradient Spin Echo (d-PGSE) MR experiment was used to measure and assess the degree of local diffusion anisotropy in brain gray matter, and in a novel "gray matter" phantom that consists of randomly oriented tubes filled with water. In both samples, isotropic diffusion was observed at a macroscopic scale while anisotropic diffusion was observed at a microscopic scale, however, the nature of the resulting echo attenuation profiles were qualitatively different. Gray matter, which contains multiple cell types and fibers, exhibits a more complicated echo attenuation profile than the phantom. Since microscopic anisotropy was observed in both samples in the low q regime comparable to that achievable in clinical scanner, it may offer a new potential contrast mechanism for characterizing gray matter microstructure in medical and biological applications. (C) 2007 Published by Elsevier Inc.