[Elental prevented and reduced oral mucositis during chemotherapy in patients esophageal cancer].
[Elental prevented and reduced oral mucositis during chemotherapy in patients esophageal cancer].
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Elental预防和减轻食管癌患者化疗期间口腔粘膜炎的作用[J].
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
T. Yoshioka
中科院分区：
文献类型：
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作者：
Tadahisa Fukui;Yuriko Itoh;M. Orihara;K. Yoshizawa;Hiroaki Takeda;S. Kawada;T. Yoshioka
口腔炎是食道癌患者化疗后常见的一种副作用，但目前尚无标准的治疗方法。众所周知，活性氧是化疗或放疗引起口腔炎的原因之一，一些报告表明，口服补充谷氨酰胺可能会减少它们的影响。Elental®是一种广泛使用的营养补充剂，其包装中含有1932毫克L-谷氨酰胺(特别高)。因此，我们研究了Elental®Mey对口腔粘膜炎的预防或减轻作用。15例食道癌患者接受了化疗，其中6例有一级口腔粘膜炎。所有6名患者都进入了调查，并接受了7个疗程的Elental®治疗。经过7个疗程后，所有6名患者的口腔粘膜炎从1级下降到0级。这一结果表明Elental®对口腔粘膜炎具有预防或减轻作用。
Stomatitis is a side effect caused frequently by chemotherapy in patients with esophageal cancer, but a standard treatment for it has not been established. Reactive oxygen species are known to be among the causes of stomatitis induced by chemotherapy or radiotherapy, and some reports suggest that their influences might be reduced by the oral supplementation of glutamine. Elental® is one of the widely-used nutritional supplements, and its pack contains 1, 932 mg of L-glutamine (an especially high amount.). Therefore, we examined the preventive or reducing effects Elental® mey have on oral mucositis. Fifteen patients with esophageal cancer received chemotherapy, six of whom had grade one oral mucositis. All of those six patients entered the investigation, and seven courses of Elental® were administered. After seven courses, all six patients oral mucositis declined from grade 1 to grade 0. This result suggests that Elental® has preventive or reducing effects on oral mucositis.