Anti-gout nor-oleanane triterpenoids from the leaves of Stauntonia brachyanthera
Anti-gout nor-oleanane triterpenoids from the leaves of Stauntonia brachyanthera
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野木瓜叶中的抗痛风去甲齐墩果烷三萜类化合物
DOI：
10.1016/j.bmcl.2016.04.048
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发表时间：
2016
影响因子：
2.7
通讯作者：
Meng Da-li
中科院分区：
文献类型：
--
作者：
Liu Xuan-li;Li Shuang;Meng Da-li
为了从天然资源中寻找更多具有抗痛风活性的化合物，对短花木通的叶进行了植物化学研究，分离得到11个降墩果烷三萜类化合物，其中4个为新化合物。酸解后，通过1D、2D核磁共振、高分辨质谱和高效液相色谱确证了它们的结构。Brachyantheraoside B4(3)和3-O-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl-30-norolean-12，20(29)-dien-28-oic酸(8)对黄嘌呤氧化酶有明显的抑制作用，IC50值分别为0.2和18.5nμM。Brachyantheraoside C2(2)对XO也有一定的抑制作用。还总结了一级构效关系，揭示了三个降墩果烷三萜类化合物的抗痛风活性及其作为治疗痛风候选化合物的可能性。降墩果烷三萜类化合物的发现也拓宽了人们对抗痛风药物的研究思路，促进了抗痛风药物的全面发展。短毛花药。
With the aim of finding more potential anti-gout compounds from natural resources, a phytochemical study on the leaves ofStauntonia brachyantherawas carried out, which led to the isolation of 11 nor-oleanane triterpenoids, including 4 new ones. Their structures were determined by the comprehensive 1D, 2D NMR, HRMS, and HPLC analysis after acid hydrolysis. Brachyantheraoside B4(3) and 3-O-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid (8) exhibited significant inhibitory activities on xanthine oxidase with IC50values of 0.20 and 18.5 μM, respectively. Brachyantheraoside C2(2) also showed moderate effects on XO. A primary structure–activity relationship was also summarized, which revealed the anti-gout abilities of three nor-oleanane triterpenoids and their potential possibilities as the candidate compounds for the treatment of gout. The discovery of nor-oleanane triterpenoids also widens people’s idea for the study of anti-gout agents and promotes the comprehensive development ofS. brachyanthera.