Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst.
Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst.
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DOI：
10.1021/ja074003o
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发表时间：
2008-03
影响因子：
15
通讯作者：
T. Kano;M. Ueda;K. Maruoka
中科院分区：
文献类型：
--
作者：
T. Kano;M. Ueda;K. Maruoka
报道了新型轴向手性双官能团氨基醇(S)-1D催化醛与NiS的直接不对称碘化反应。这种方法是催化和高对映选择性合成光学活性α-碘醛的罕见例子。
A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.