Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
复制标题
DOI：
10.1016/s0016-5085(00)70261-7
复制
发表时间：
2000-03-01
期刊：
影响因子：
29.4
通讯作者：
Chen, DS
中科院分区：
文献类型：
--
作者：
Kao, JH;Chen, PJ;Chen, DS
背景与目的：乙型肝炎病毒（HBV）已鉴定出六种基因型（A-F）；然而，HBV 致病性的基因型相关差异仍不清楚。因此，我们通过横断面研究调查了台湾 HBV 基因型的流行情况以及不同基因型与肝病严重程度之间的关联。方法：采用分子方法，对 100 名无症状携带者和 170 名经组织学证实的慢性肝病和肝细胞癌 (HCC) 患者进行了 HBV 基因型测定。结果：台湾地区已鉴定出除E基因型外的所有基因型，其中以B和C基因型为主。与年龄匹配的无症状携带者相比，C 基因型在年龄超过 50 岁的肝硬化患者和 HCC 患者中普遍存在（分别为 60% vs. 23%，P < 0.001；以及 41% vs. 15%，P = 0.005）。与年龄匹配的无症状携带者相比，B 基因型在年龄小于 50 岁的 HCC 患者中更为常见（80% vs. 52%，P = 0.03）。这种优势在年轻的 HCC 患者中更为明显（90% 的患者年龄小于或等于 35 岁），其中大多数没有肝硬化。结论：我们的数据表明，HBV 基因型 C 与更严重的肝脏疾病相关，而基因型 B 可能与台湾年轻人肝癌的发生有关。然而，还需要进行额外的大规模纵向研究来确认 HBV 基因型与肝病严重程度和临床结果的关系。
Background & Aims: Six genotypes (A-F) of hepatitis B virus (HBV) have been identified; however, the genotype-related differences in the pathogenicity of HBV remain unknown. Therefore, we investigated the prevalence of HBV genotypes in Taiwan and the association between distinct genotypes and severity of liver disease in a cross-sectional study. Methods: Using a molecular method, HBV genotypes were determined in 100 asymptomatic carriers and in 170 patients with histologically verified chronic liver disease and hepatocellular carcinoma (HCC). Results: All genotypes except genotype E were identified in Taiwan, and genotypes B and C were predominant. Genotype C was prevalent in patients with cirrhosis and in those with HCC who were older than 50 years compared with age-matched asymptomatic carriers (60% vs. 23%, P < 0.001, and 41% vs. 15%, P = 0.005, respectively). Genotype B was significantly more common in patients with HCC aged less than 50 years compared with age-matched asymptomatic carriers (80% vs. 52%, P = 0.03). This predominance was more marked in younger patients with HCC (90% in those aged less than or equal to 35 years), most of whom did not have cirrhosis. Conclusions: Our data suggest that HBV genotype C is associated with more severe liver disease and genotype B may be associated with the development of HCC in young Taiwanese. However, additional large-scale longitudinal studies are needed to confirm the relationship of HBV genotypes to liver disease severity and clinical outcomes.