Association between polymorphism of the transforming growth factor-β1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament
Association between polymorphism of the transforming growth factor-β1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament
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DOI：
10.1097/00007632-200307010-00013
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发表时间：
2003-07-01
期刊：
影响因子：
3
通讯作者：
Kimura, T
中科院分区：
文献类型：
--
作者：
Kawaguchi, Y;Furushima, K;Kimura, T
研究设计：探讨转化生长因子-β1基因(转化生长因子-β1)基因多态性(信号序列中的T-和C转换)与后纵韧带骨化(OPLL)的关系。目的：探讨转化生长因子-β1基因多态性与口腔扁平苔藓放射学特征的关系。后纵韧带骨化有很强的遗传背景。有几个基因参与了OPLL的表达。转化生长因子-β1存在于OPLL邻近区域的骨化基质和软骨细胞中。对369例OPLL患者和258例正常对照的转化生长因子-Tbeta1等位基因分布(TT、TC和CC)进行了比较。分析颈、胸、腰椎OPLL的X线表现和骨化区宽度与等位基因频率的关系。OPLL组与对照组比较，OPLL类型和TGF-Tbeta1等位基因骨化区宽度差异无统计学意义。然而，在具有“TC”或“CC”等位基因的患者中，OPLL多见于颈、胸和/或腰椎。转化生长因子-β1基因多态性与OPLL的发生无关，而与骨化病变的面积有关。C等位基因可能是除宫颈病变外其他部位OPLL患者的危险因素。
Study Design: A study was conducted to examine the relation between the transforming growth factor-beta1 (TGF-beta1) polymorphism (T-->C transition in the signal sequence) and ossification of the posterior longitudinal ligament (OPLL).Objective. To investigate the association between the polymorphism of TGF-beta1 and the radiologic characteristics of OPLL.Summary of Background Data. Ossification of the posterior longitudinal ligament has a strong genetic background. Several genes contribute to the expression of OPLL. Transforming growth factor-beta1 is present in the ossified matrix and chondrocytes of cartilage adjacent to areas of OPLL.Methods. The difference in the TGF-Tbeta1 allele distribution ("TT," "TC," and "CC") between 369 patients with OPLL and 258 control subjects was assessed. The relations between the allele frequency and radiologic features of OPLL involving the cervical, thoracic, and lumbar spine and the width of the ossification area were evaluated.Results. There was no statistical difference with respect to the type of OPLL and the width of the ossification area for the TGF-Tbeta1 allele between the OPLL and the control groups. However, in the patients with "TC" or "CC" alleles, OPLL frequently was found in the cervical, thoracic, and/or lumbar spine.Conclusions. Transforming growth factor-beta1 polymorphism is not a factor associated with the occurrence of OPLL, but rather a factor related to the area of the ossified lesion. The "C" allele might be a risk factor for patients with OPLL in other areas in addition to the cervical lesion.