IMPAIRED MYOCARDIAL-FUNCTION IN SPONTANEOUSLY HYPERTENSIVE RATS WITH HEART-FAILURE
IMPAIRED MYOCARDIAL-FUNCTION IN SPONTANEOUSLY HYPERTENSIVE RATS WITH HEART-FAILURE
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DOI：
10.1152/ajpheart.1991.260.1.h136
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发表时间：
1991-01-01
影响因子：
--
通讯作者：
BING, OHL
中科院分区：
文献类型：
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作者：
CONRAD, CH;BROOKS, WW;BING, OHL
我们观察到许多18 - 24月龄的自发性高血压大鼠（SHR）出现提示心力衰竭的结果，包括胸腔和心包积液、左心房血栓和右心室肥大。 在这些动物（SHR-F）、年龄匹配的无心力衰竭证据的SHR（SHR-NF）和非高血压对照组（WKY）中研究了孤立的左心室乳头肌功能。 与SHR-NF（7.17 +/- 0.94）和WKY（6.17 +/- 1.00）相比，SHR-F的制剂显示主动张力发展的抑制（3.58 +/- 1.75 g/mm 2;平均值+/- SD）（P < 0.01）。 与SHR-NF组（1.60 +/-0.30; P < 0.05）和WKY组（2.15 +/- 0.48; P < 0.01）相比，SHR-F组（0.95 +/-0.38长度/s）的缩短速度也受到抑制。 在18月龄以前未发现肌肉功能的抑制。 因此，老龄SHR是一个模型，其中可以观察到从慢性稳定的左心室肥厚到明显的心力衰竭的过渡。 此外，从SHR与心力衰竭的左心室乳头肌显示出显着的收缩功能障碍的证据，这表明内在心肌功能的损害是心力衰竭的发展。
We have observed that many spontaneously hypertensive rats (SHR) between the ages of 18 and 24 mo develop findings suggestive of heart failure, including pleural and pericardial effusions, left atrial thrombi, and right ventricular hypertrophy. Isolated left ventricular papillary muscle function was studied in these animals (SHR-F), in age-matched SHRs without evidence of heart failure (SHR-NF), and in nonhypertensive controls (WKY). Preparations from SHR-F showed depression of active tension development (3.58 +/- 1.75 g/mm2; means +/- SD) compared with both SHR-NF (7.17 +/- 0.94) and WKY (6.17 +/- 1.00) (P < 0.01). Shortening velocity was also depressed in SHR-F (0.95 +/- 0.38 lengths/s) compared with SHR-NF (1.60 +/- 0.30; P < 0.05) and WKY groups (2.15 +/- 0.48; P < 0.01). Depression of muscle function was not found before 18 mo of age. Thus the aging SHR is a model in which one can observe the transition from chronic stable left ventricular hypertrophy to overt heart failure. Furthermore, left ventricular papillary muscles from SHRs with heart failure show evidence of significant contractile dysfunction, suggesting that impairment of intrinsic myocardial function underlies the development of heart failure.