Pharmacokinetics of terbinafine in the nail.
Pharmacokinetics of terbinafine in the nail.
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特比萘芬在指甲中的药代动力学。
DOI：
10.1111/j.1365-2133.1992.tb00006.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
A. Finlay
中科院分区：
文献类型：
--
作者：
A. Finlay
口服特比萘芬是治疗皮肤真菌性甲真菌病的有效方法，可能是因为它能迅速到达指甲的感染区域，并具有杀真菌的浓度。为了规划最佳的临床剂量方案，有必要知道特比萘芬通过甲板的运动速率，达到的浓度，以及停止治疗后在甲板上的持久性。在一项研究中，12名患者接受特比萘芬250毫克/天，长达48周，测量的特比萘芬在远端指甲剪证明，该药物是第一次检测后3-18周开始治疗。迅速达到0.25-0.55纳克/毫克的水平，并保持稳定。未受影响的指甲远端剪下的特比萘芬浓度相似，在受影响的指甲。虽然指甲的平均浓度在皮肤真菌的杀菌范围内，但受感染指甲的解剖结构可能导致相对受保护的感染区域。这导致在某些情况下观察到的皮肤真菌感染偶尔持续或复发。然而，这项研究的结果证明进一步的试验“短期”口服特比萘芬治疗甲真菌病。目前的一项研究正在解决口服剂量与指甲药物浓度及其在甲板上的持久性的关系。
Oral terbinafine is an effective therapy for dermatophyte onychomycosis, presumably because it reaches the infected areas of the nail rapidly and in fungicidal concentrations. For planning optimal clinical dosage regimes, it is necessary to know the rate of terbinafine movement through the nail plate, the concentrations achieved, and the persistence in the nail plate after stopping treatment. In a study of 12 patients receiving terbinafine at 250 mg/day for up to 48 weeks, measurement of terbinafine in distal nail clippings demonstrated that the drug was first detectable 3-18 weeks after starting therapy. A level of 0.25-0.55 ng/mg was quickly achieved and remained stable. Concentrations of terbinafine in distal clippings of unaffected nails were similar to those in affected nails. Although the average nail concentrations are within the fungicidal range for dermatophytes, the anatomy of an infected nail may result in relatively protected areas of infection. This results in the occasional persistence or recurrence of dermatophytic infection observed in some cases. However, the results of this study justify further trials of 'short-term' oral terbinafine therapy for onychomycosis. A current study is addressing the relationship of oral dosage to nail drug concentration and its later persistence in the nail plate.