2,3-Bisphosphoglycerate protects mitochondrial and cytosolic proteins from proteolytic inactivation.

2,3-Bisphosphoglycerate protects mitochondrial and cytosolic proteins from proteolytic inactivation.
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2,3-双磷酸甘油酸可保护线粒体和胞质蛋白免遭蛋白水解失活。

DOI:
10.1016/0006-291x(87)91468-9
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发表时间:
1987
影响因子:
3.1
通讯作者:
S. Grisolía
S. Grisolía
中科院分区:
生物学4区
文献类型:
--
作者:
E. Roche;E. Knecht;S. Grisolía

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2,3-二磷酸甘油酸的生理浓度与许多组织中的浓度相似,可有效保护鸟氨酸转氨甲酰酶 (OTC) 免受溶酶体破裂导致的蛋白水解失活。 2,3-二磷酸甘油酸还可以保护许多其他线粒体和胞浆蛋白,例如谷氨酸脱氢酶 (GDH) 和 3-磷酸甘油醛脱氢酶 (GAPDH),防止被破碎的溶酶体和其他蛋白酶水解。因此,表明2,3-二磷酸甘油酸可能在控制某些蛋白质的降解速率中发挥重要作用,这可以解释其在某些细胞中的高浓度。
2,3-bisphosphoglycerate at physiological concentration similar to that found in many tissues protects effectively ornithine transcarbamoylase (OTC) from proteolytic inactivation by broken lysosomes. 2,3-bisphosphoglycerate protects also many other mitochondrial and cytosolic proteins, such as glutamate dehydrogenase (GDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from proteolysis by broken lysosomes and other proteases. It is, thus, suggested that 2,3-bisphosphoglycerate may play an important role in the control of the degradative rates of some proteins, which may explain its high concentration in certain cells.
红细胞中 2,3-二磷酸甘油酸对酪蛋白激酶 II 的调节。
DOI: --
发表时间: 1984
期刊: The Journal of biological chemistry
影响因子: --
作者:
Hathaway,GM;Traugh,JA
通讯作者: Traugh,JA