VISUAL DYSFUNCTION AMONG STYRENE-EXPOSED WORKERS
VISUAL DYSFUNCTION AMONG STYRENE-EXPOSED WORKERS
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DOI：
10.5271/sjweh.53
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发表时间：
1995-10-01
影响因子：
6.3
通讯作者：
DROLET, D
中科院分区：
文献类型：
--
作者：
CAMPAGNA, D;MERGLER, D;DROLET, D
目的本研究进行了检查视觉功能和职业暴露styrene.Methods之间的关系，共有128名工人（总人口的85%），从三个玻璃钢厂在加拿大，同意参加这项研究。在评估近视力（National Optical Visual Chart）、辨色（Lanthony D-15去饱和板）和近对比敏感度（Vistech 6000）的前几天进行环境和生物测量。对81名工人进行了分析，近视力至少1分钟的是在0.5 m。结果受试者相对年轻[29（SD 8）年]，与小资历[5（SD 4）年]。苯乙烯暴露8小时的范围为6至937（第一个四分位数21 mg . m（-3），第三四分位数303 mg . m（-3）），取决于作业现场。尿扁桃酸的终末偏移浓度范围为不可检测到1.90 mmol。mmol肌酐（-1）。显着的正相关关系被发现之间的内部和外部苯乙烯暴露测量和色觉丧失调整年龄，饮酒量和资历的多元回归分析。多元回归分析显示，6、12周期度（-1）时，尿扁桃酸的末端位移浓度与对比敏感度呈负相关。Logistic多元回归模型显示，尿扁桃酸的末端偏移浓度与视力模糊、流泪和眼刺激的患病率有关。结论苯乙烯暴露与早期色觉和对比度视觉功能障碍呈正相关。
Objectives The present study was undertaken to examine the relation between visual functions and occupational exposure to styrene.Methods A total of 128 workers (85% of the total population), from three glass-reinforced plastics plants in Canada, agreed to participate in the study. Environmental and biological measures were made on the day(s) prior to the assessment of near visual acuity (National Optical Visual Chart), chromatic discrimination (Lanthony D-15 desaturated panel), and near contrast sensitivity (Vistech 6000). The analyses were performed on 81 workers with near visual acuity of at least 1 min of are at 0.5 m.Results The subjects were relatively young [29 (SD 8) years], with little seniority [5 (SD 4) years]. Styrene exposure for 8 h ranged from 6 to 937 (first quartile 21 mg . m(-3), third quartile 303 mg . m(-3)), depending on the job site. The end-shift concentrations of urinary mandelic acid ranged from nondetectable to 1.90 mmol . mmol creatinine(-1). Significant positive relations were found between the internal and external styrene exposure measurements and color vision loss adjusted for age, alcohol consumption, and seniority in a multiple regression analysis. The multiple regression analysis also showed that the end-shift concentration of urinary mandelic acid was inversely related to contrast sensitivity at 6 and 12 cycles degree(-1). Logistic multiple regression models indicated that the end-shift concentration of urinary mandelic acid was related to the prevalences of blurred vision, tearing, and eye irritation.Conclusions These findings suggest that there is a positive relation between styrene exposure and early color and contrast vision dysfunction.