The effect of anterior cruciate ligament injury on knee joint function under a simulated muscle load: A three-dimensional computational simulation
The effect of anterior cruciate ligament injury on knee joint function under a simulated muscle load: A three-dimensional computational simulation
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DOI：
10.1114/1.1484219
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发表时间：
2002-05-01
影响因子：
3.8
通讯作者：
Gill, T
中科院分区：
文献类型：
--
作者：
Li, G;Suggs, J;Gill, T
了解前交叉韧带 (ACL) 损伤或重建后各种因素对膝关节行为的生物力学影响，有助于制定 ACL 损伤的最佳手术治疗方法，更好地恢复正常的膝关节功能。本文介绍了三维 (313) 计算膝关节模型在膝关节运动学响应模拟肌肉负荷的参数研究中的应用。利用同一尸体人体膝关节标本的磁共振图像和生物力学实验数据构建膝关节模型。将计算模型预测的膝关节运动学与在各种负载条件和屈曲角度下从不同样本测量的运动学进行了比较。总体而言，模型预测在实验数据范围内。然后，当膝关节 ACL 缺陷时，该模型可用于预测膝关节运动、韧带力和接触压力，以响应模拟股四头肌力。通过降低模型中 ACL 的刚度来模拟部分 ACL 损伤。结果表明，即使 ACL 刚度减少 75%，ACL 仍然承受完整 ACL 承受的大量负载（超过 58%）。与具有完整 ACL 的膝关节相比，运动学（胫骨平移和旋转）变化小于 20%。 3D 计算模型可以成为模拟 ACL 重建后影响膝关节功能的不同变量的强大工具，例如 ACL 移植物的初始张力、移植物的插入部位、多束移植物、移植物材料和各种生理负荷条件。 (C) 2002 年生物医学工程学会。
Understanding the biomechanical effect of various factors on knee behavior after anterior cruciate ligament (ACL) injury or reconstruction is instrumental for the development of an optimal surgical treatment of ACL injury that can better restore normal knee function. This paper presents the application of a three-dimensional (313) computational knee model for parametric studies of knee kinematics in response to simulated muscle loads. The knee model was constructed using the magnetic resonance images and biomechanical experimental data of the same cadaveric human knee specimen. The kinematics of the knee predicted by the computational model was compared with that measured from different specimens in a wide range of loading conditions and flexion angles. In general, the model predictions were within the range of experimental data. The model was then used to predict knee motion, ligament forces, and contact pressure in response to a simulated quadriceps force when the knee was ACL deficient. Partial ACL injury was simulated by reducing the stiffness of the ACL in the model. The results demonstrated that even with a reduction of 75% of the ACL stiffness, the ACL still carried a significant amount of the load (more than 58%) carried by an intact ACL. The kinematics (both tibial translation and rotation) varied less than 20% compared to that of the knee with intact ACL. The 3D computational model can be a powerful tool to simulate different variables that would influence knee function after ACL reconstruction, such as the initial tension of the ACL graft, the insertion sites of the graft, multibundle grafts, graft materials, and various physiological loading conditions. (C) 2002 Biomedical Engineering Society.