Association Between Period 3 Gene Polymorphisms and Adverse Effects of Antidepressants for Major Depressive Disorder
Association Between Period 3 Gene Polymorphisms and Adverse Effects of Antidepressants for Major Depressive Disorder
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3期基因多态性与抗抑郁药治疗重度抑郁症不良反应之间的关联
DOI：
10.1089/gtmb.2019.0065
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发表时间：
2019
影响因子：
1.4
通讯作者：
Liu Zhifen
中科院分区：
文献类型：
--
作者：
Xu Yifan;Ma Huiying;Zhao Ting;Wen Dan;Wen Yujiao;Qiao Dan;Liu Zhifen
目的：包括周期3（Per 3）在内的昼夜节律基因与重度抑郁症（MDD）相关，并影响患者对选择性5-羟色胺再摄取抑制剂（SSRI）抗抑郁药的反应。本研究的目的是确定Per 3的三个单核苷酸多态性（SNPs）（rs 10746473，rs 228697和rs 228729），MDD症状，SSRIs.Materials和方法的不良反应之间可能存在的关联：共600例MDD患者谁已与SSRIs治疗。采用17项汉密尔顿抑郁量表（HAMD 17）评定症状和疗效。此外，使用治疗后出现的症状量表/UKU消费者满意度评定量表（TESS/UKU）评估不良反应。结果：Per 3rs 228697 CC基因型的睡眠因子分显著高于CG基因型（F= 4.027，p = 0.046）。此外，与CC基因型相比，rs 228729 TC基因型与兴奋/激动（p= 0.002，OR [比值比] = 4.049），静坐不能（p= 0.014，OR = 4.905）和体重减轻（p= 0.041，OR = 2.287）的风险更大相关。结论：Per 3基因多态性可预测SSRIs的不良反应及服药依从性。
Aims:Circadian rhythm genes includingPeriod 3(Per3) are associated with major depressive disorder (MDD) and have an effect on the patient's response to selective serotonin reuptake inhibitor (SSRI) antidepressants. The aim of this study was to identify possible associations between three single nucleotide polymorphisms (SNPs) ofPer3(rs10746473, rs228697, and rs228729), the MDD symptoms, and adverse effects of SSRIs.Materials and Methods:A total of 600 MDD patients who had been treated with SSRIs were enrolled. The 17-item Hamilton Rating Scale for Depression (HAMD17) was used to evaluate symptoms and treatment efficacy. In addition, the Treatment Emergent Symptom Scale/UKU Consumer Satisfaction Rating Scale (TESS/UKU) was used to assess adverse effects. ThePer3locus was genotyped by PCR and DNA sequencing.Results:ThePer3rs228697 CC genotype was associated with a higher sleep factor score when compared with the CG genotype (F= 4.027,p= 0.046). In addition, the rs228729 TC genotype was associated with a greater risk of suffering from excitement/agitation (p= 0.002, OR [odds ratio] = 4.049), akathisia (p= 0.014, OR = 4.905) and weight loss (p= 0.041, OR = 2.287) when compared with the CC genotype. Finally, the rs10746473 AA genotype patients were more likely to suffer from dizziness (p= 0.042, OR = 0.362) and the GA genotype patients from tachycardia (p= 0.015, OR = 0.340) when compared with those with GG genotype.Conclusion:ThePer3gene variants in patients can predict adverse effects of SSRIs and drug compliance.