CENTRAL GUSTATORY LESIONS .2. EFFECTS ON SODIUM APPETITE, TASTE-AVERSION LEARNING, AND FEEDING BEHAVIORS
CENTRAL GUSTATORY LESIONS .2. EFFECTS ON SODIUM APPETITE, TASTE-AVERSION LEARNING, AND FEEDING BEHAVIORS
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DOI：
10.1037/0735-7044.105.6.944
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发表时间：
1991-12-01
影响因子：
1.9
通讯作者：
NORGREN, R
中科院分区：
文献类型：
--
作者：
FLYNN, FW;GRILL, HJ;NORGREN, R
摄取和味觉反应性试验用于确定双侧损伤的孤立束核（NST）、臂旁核（PBN）和丘脑腹侧后内侧核（VPMpc）的味觉部分对几种复杂的摄取行为的影响。在实验1中，PBN和NST病变阻断，VPMpc病变损害盐性食欲行为表达。在第二个实验中，丙氨酸与注射LiCl配对。对照大鼠以及NST和VPMpc病变大鼠获得了味觉厌恶，而PBN病变大鼠没有。在第三个实验中，所有动物在注射胰岛素2 U/kg和2-脱氧-d -葡萄糖250 mg/kg后，摄食量均增加，营养胃负荷后，摄食量受到抑制。
Intake and taste reactivity tests were used to determine the effects of bilateral lesions of the gustatory portions of the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN), and the ventral posteromedial nucleus of the thalamus (VPMpc) on several complex ingestive behaviors. In the 1st experiment, lesions of the PBN and the NST blocked, and VPMpc lesions impaired, the behavioral expression of salt appetite. In the 2nd experiment, alanine was paired with injections of LiCl. Control rats as well as rats with NST and VPMpc lesions acquired the taste aversion, but rats with PBN lesions did not. In the 3rd experiment, all animals increased their food intake after injections of 2 U/kg insulin and 250 mg/kg 2-deoxy-D-glucose, and their food intake was suppressed after nutritive stomach loads.