Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol
Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol
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DOI：
10.1046/j.1463-1326.2003.00254.x
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发表时间：
2003-03-01
影响因子：
5.8
通讯作者：
Kumar, S
中科院分区：
文献类型：
--
作者：
Valsamakis, G;Chetty, R;Kumar, S
目的：脂联素是一种由脂肪组织分泌的30 kDa蛋白质。本研究的目的是比较印度裔和高加索男性受试者的血清脂联素水平及其与脂肪形态和代谢参数的关系。方法：对48名糖尿病和非糖尿病男性受试者进行研究。一名观察者进行了血压和人体测量。测定空腹血糖、胰岛素、血脂和脂联素(用放射免疫法测定)。结果：糖尿病患者和体重指数匹配的非糖尿病患者的血清脂联素水平差异无统计学意义。然而，与体重指数匹配的高加索人相比，印亚裔人的血清脂联素水平较低，[中位数脂联素(四分位数范围)分别为3.3(2.1-3.9)和4.9(3.5-6.6)µg/ml(p=0.016)]。单因素分析显示，糖尿病组(p=0.039)和非糖尿病组(p=0.0098)的血清脂联素与高密度脂蛋白呈正相关。糖尿病患者腰围(p=0.02)、矢状径(p=0.04)与血清脂联素水平呈负相关。对所有受试者的腰围、高密度脂蛋白、空腹胰岛素、年龄、糖尿病、民族等因素进行多元回归分析，发现高密度脂蛋白是影响血清脂联素水平的最佳因素。与印亚人相比，高加索人的血清脂联素水平更高。需要进一步的研究来探索脂联素与高密度脂蛋白胆固醇之间的联系的基础，以及印度-亚洲人水平较低的原因。
Aim: Adiponectin is a 30-kDa protein secreted by adipose tissue. The aim of the present study was to compare serum adiponectin in male Indo-Asian and Caucasian subjects and examine its association with fat topography and metabolic parameters.Methods: Diabetic and non-diabetic male subjects (n = 48) were studied. A single observer carried out blood pressure and anthropometric measurements. Serum glucose, insulin, lipid profile and adiponectin (measured by RIA) were measured on a fasting sample.Results: There was no statistically significant difference in serum adiponectin between diabetic and BMI-matched non-diabetic subjects. However, serum adiponectin was lower in Indo-Asians compared with BMI-matched Caucasians, [median adiponectin (interquartile range) 3.3 (2.1-3.9) vs. 4.9 (3.5-6.6) mug/ml respectively (p = 0.016)]. Univariate analysis showed serum adiponectin to be positively associated with HDL in diabetic (p = 0.039) and non-diabetic subjects (p = 0.0098). Waist circumference (p = 0.02), saggital diameter (p = 0.04) were negatively correlated with serum adiponectin in diabetic subjects. Multiple regression analysis including waist, HDL, fasting insulin, age, diabetes and ethnicity in all subjects showed HDL to be the best predictor of serum adiponectin.Conclusions: Serum adiponectin is associated with HDL cholesterol and central obesity. Caucasians have higher serum adiponectin levels compared with Indo-Asians. Further studies are needed to explore basis for the association of adiponectin with HDL cholesterol and the reason for lower levels in Indo-Asians.