Imaging the pathology of Alzheimer's disease:: amyloid-imaging with positron emission tomography
Imaging the pathology of Alzheimer's disease:: amyloid-imaging with positron emission tomography
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DOI：
10.1016/s1052-5149(03)00092-3
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发表时间：
2003-11-01
影响因子：
2.3
通讯作者：
Mathis, CA
中科院分区：
文献类型：
--
作者：
Klunk, WE;Engler, H;Mathis, CA
阿尔茨海默病（AD）发病率的急剧上升进一步增加了由美国人口老龄化引起的相当大的公共卫生负担。AD最典型的病理标志是神经炎性斑块和神经纤维缠结。使用正电子发射断层扫描和淀粉样蛋白沉积的选择性标记物的能力有望大大改变我们诊断和管理AD患者的方式。
The steep rise in the incidence of Alzheimer's disease (AD) has further added to the considerable public health burden caused by aging of the United States population. Among the most characteristic pathologic hallmarks of AD are neuritic plaques and neurofibrillary tangles. The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD.