A case of neonatal pemphigus vulgaris with co-existing BP180 autoantibodies
A case of neonatal pemphigus vulgaris with co-existing BP180 autoantibodies
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DOI：
10.1111/pde.14059
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发表时间：
2019-11-27
影响因子：
1.5
通讯作者：
Silverberg, Nanette
中科院分区：
文献类型：
--
作者：
Fenner, Justine;Min, Michelle S.;Silverberg, Nanette
一位37岁初产妇，既往有复发性、疼痛性、局部类固醇反应性口腔水疱病史，其男性新生儿出生时躯干有水疱。新生儿天疱疮的诊断是在新生儿和母亲被发现有升高的粘粒蛋白3 （Dsg3）抗体，并结合寻常型天疱疮的组织病理学特征。有趣的是，新生儿和母亲都有BP180抗体水平升高，这在大疱性类天疱疮中很常见。这种情况是独特的，因为它描绘了新生儿天疱疮，一个已经罕见的条件，复杂的存在BP180抗体。
A male neonate was born with blisters on the trunk to a 37-year-old primigravid woman with a past medical history of recurrent, painful, topical steroid-responsive oral blisters. The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. Interestingly, both neonate and mother also had elevated levels of BP180 antibodies, classically seen in bullous pemphigoid. This case is unique in that it portrays neonatal pemphigus, an already rare condition, complicated by the presence of BP180 antibodies.