Measurement of frontal lobe functional activation and related systemic effects: A near-infrared spectroscopy investigation
Measurement of frontal lobe functional activation and related systemic effects: A near-infrared spectroscopy investigation
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DOI：
10.1007/978-0-387-74911-2_44
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Elwell, Clare E.
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文献类型：
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作者：
Tachtsidis, Ilias;Leung, Terence S.;Elwell, Clare E.
近红外光谱 (NIRS) 已用于测量大脑氧合血红蛋白和脱氧血红蛋白 (Delta[HbO(2)]、Delta[HHb]) 响应功能激活的变化。此前已有报道称，运动皮层功能激活期间心率会增加。本研究的目的是调查额叶皮层功能激活过程中的系统变化。记录 6 分钟内对不同难度（4 个字母和 7 个字母）的字谜演示的反应。 Hamamatsu NIRO 200 NIRS 系统使用修正的比尔朗伯定律 (MBL) 记录 Delta[HbO(2)] 和 Delta[HHb]，并利用空间分辨光谱 (SRS) 在左右额叶半球记录组织氧合指数 (TOI)。连续测量平均血压（MBP）和心率（HR）。九名年轻健康志愿者（平均年龄 23 岁）参与了分析。在 Anagram 解决过程中，NIRS 和系统信号均观察到与任务相关的显着变化，[HbO(2)] 和 [HHb] 增加，伴随着 MBP 和 HR 的变化。发现在不同志愿者的额叶区域测量的 [HbO(2)] 和 [HHb] 信号与 MBP 信号有不同的关联。必须考虑这些系统变化对测量的 NIRS 信号的影响。
Near-infrared spectroscopy (NIRS) has been used to measure changes in cerebral oxy- and deoxy- haemoglobin (Delta[HbO(2)], Delta[HHb]) in response to functional activation. It has been previously reported that during functional activation of the motor cortex heart rate increases. The aim of this study was to investigate systemic changes during functional activation of the frontal cortex. The responses to anagram presentations with varying difficulty (4-Letters and 7-Letters) over a 6 minute period were recorded. A Hamamatsu NIRO 200 NIRS system recorded Delta[HbO(2)] and Delta[HHb] using the modified Beer Lambert law (MBL) and tissue oxygenation index (TOI) employing spatial resolved spectroscopy (SRS) over the left and right frontal hemisphere. Mean blood pressure (MBP) and heart rate (HR) were measured continuously. Nine young healthy volunteers (mean age 23) were included in the analysis. Significant task related changes were observed in both the NIRS and systemic signals during the anagram solving with increases in [HbO(2)] and [HHb] accompanied by changes in MBP and HR. The [HbO(2)] and [HHb] signals measured over the frontal region were found to have a varying association with the MBP signal across different volunteers. The effect of these systemic changes on measured NIRS signals must be considered.