NONSMOKING, NON-ALPHA1-ANTITRYPSIN DEFICIENCY-INDUCED EMPHYSEMA IN NONSMOKERS WITH HEALED SPONTANEOUS PNEUMOTHORAX, IDENTIFIED BY COMPUTED-TOMOGRAPHY OF THE LUNGS
NONSMOKING, NON-ALPHA1-ANTITRYPSIN DEFICIENCY-INDUCED EMPHYSEMA IN NONSMOKERS WITH HEALED SPONTANEOUS PNEUMOTHORAX, IDENTIFIED BY COMPUTED-TOMOGRAPHY OF THE LUNGS
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DOI：
10.1378/chest.103.2.433
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发表时间：
1993-02-01
期刊：
影响因子：
9.6
通讯作者：
WIMAN, LG
中科院分区：
文献类型：
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作者：
BENSE, L;LEWANDER, R;WIMAN, LG
该病例对照研究基于对27例经放射学证实的自发性气胸（SP）非吸烟患者和10例健康的从不吸烟的对照受试者的调查。患者和对照组的后前位和侧位X线片均正常。他们都接受了相同的临床、实验室和放射学检查，包括肺部计算机断层扫描（CT），目的是检测任何肺实质变化。27名患者中有22名（81%）在CT上检测到肺气肿样变化（ELC），如果加上介入手术期间检测到的ELC病例，死亡频率增加到24/27（89%）。在20例单侧SP患者中，在20个SP受累肺中的13个中发现至少一个ELC，但仅在20个未诊断为SP的肺中的5个中发现（p0.05），并且在放射学上外周区域比中心区域更常见（p
This case-control study is based on an investigation of 27 nonsmoking patients with radiologically verified spontaneous pneumothorax (SP) and ten healthy never-smoker control subjects. The posteroanterior and lateral radiographs of patients and control subjects were normal. They were all submitted to the same clinical, laboratory, and radiologic examinations, including computed tomography (CT) of the lungs, with the aim of detecting any parenchymatous lung changes. Emphysema-like changes (ELCs) were detected on CT in 22 (81 percent) of the 27 patients, and if the ELC cases detected during interventional surgery are added, die frequency increases to 24/27 (89 percent). In 20 patients with unilateral SP, at least one ELC was found in 13 of the 20 SP-affected lungs, but only in five of the 20 lungs that were not diagnosed as having SP (p0.05) and more frequently in the radiologically peripheral than in central regions (p