Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis
Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis
复制标题
DOI：
10.1039/c1jm13064a
复制
发表时间：
2011-01-01
影响因子：
--
通讯作者：
Kim, Kwangmeyung
中科院分区：
文献类型：
--
作者：
Ryu, Ju Hee;Kim, Sun Ah;Kim, Kwangmeyung
我们开发了一种组织蛋白酶 B 敏感纳米探针 (CB-NP)，其中包含组织蛋白酶 B 底物肽探针和肿瘤靶向乙二醇壳聚糖纳米颗粒。 CB-NP可以在肿瘤组织中积累，进入肿瘤细胞，并在细胞质中响应组织蛋白酶B产生荧光信号。在荷瘤小鼠模型中的非侵入性荧光成像结果证明了CB-NP在临床领域用于肿瘤诊断的潜力。
We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields.