BDNF serum concentrations in first psychotic episode drug-naive schizophrenic patients: Associations with personality and BDNF Val66Met polymorphism
BDNF serum concentrations in first psychotic episode drug-naive schizophrenic patients: Associations with personality and BDNF Val66Met polymorphism
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DOI：
10.1016/j.lfs.2013.01.008
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发表时间：
2013-03-12
期刊：
影响因子：
6.1
通讯作者：
Antoniou, Katerina
中科院分区：
文献类型：
--
作者：
Sotiropoulou, Marianthi;Mantas, Christos;Antoniou, Katerina
目的：探讨首发精神分裂症(FEP)患者和正常对照患者血清脑源性神经营养因子(BDNF)水平、BDNFVal66Met基因多态性与人格特征的关系。为了研究他们的人格特征，我们使用了标准化的希腊版Zuckerman-Kuhlman人格问卷(ZXPQ)。结果：FEP患者血清脑源性神经营养因子水平较低(P=0.002)，ZKPQ神经质(P=0.001)和攻击-敌对(P=0.002)得分较高，而ZKPQ社交能力量表得分较低(P<0.05)。
Aims: To investigate the relationship among brain derived neurotrophic factor (BDNF) serum concentrations, BDNF Val66Met polymorphism and personality profile in drug-naive schizophrenic patients with first-episode psychosis (FEP) and healthy participants.Main methods: This cross-sectional study included fifty FEP patients and fifty healthy participants who served as controls. To study their personality profile the standardized Greek version of the Alternative Five-Factor Zuckerman-Kuhlman Personality Questionnaire (ZXPQ) was administered. Serum BDNF levels were measured and genotyping of BDNF Val66Met polymorphism was performed in patients and healthy subjects.Key findings: FEP patients presented lower BDNF serum concentrations (P=0.002) and higher scores in ZKPQ Neuroticism (P=0.001) and Aggression-Hostility (P=0.002) scales while lower scores in the ZKPQ Sociability scale (P