VASOACTIVE INTESTINAL PEPTIDE (VIP) CELLS IN PANCREAS AND GASTROINTESTINAL MUCOSA - IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY
VASOACTIVE INTESTINAL PEPTIDE (VIP) CELLS IN PANCREAS AND GASTROINTESTINAL MUCOSA - IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY
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DOI：
10.1007/bf00491069
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
SAID, SI
中科院分区：
文献类型：
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作者：
BUFFA, R;CAPELLA, C;SAID, SI
在免疫过氧化物酶和免疫荧光试验中，用纯普鲁丁VIP抗体检测到VIP免疫反应细胞在胰腺内，特别是在狗、豚鼠和人的胰岛和胃肠粘膜中。VIP免疫反应细胞在这些组织中广泛分布，在任何部位都不多见。这些细胞与超微结构鉴定的胰腺和胃肠粘膜的D1细胞有一定的相似性。正常胰腺中VIP细胞的存在可能解释了胰腺内分泌肿瘤产生VIP的原因。
Using antibodies against pure procine VIP in immunoperoxidase and immunofluorescence tests, VIP immunoreactive cells were detected in the pancreas especially in the islets and gastrointestinal mucosa of the dog, guinea pig and man. VIP immunoreactive cells were widely distributed in these tissues, never being numerous at any site. Some parallelism was noted between such cells and ultrastructurally identified D1 cells of the pancreas and gastrointestinal mucosa. The presence of VIP cells in normal pancreas may explain the occurrence of pancreatic endocrine tumors producing VIP.