SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY
SELECTIVE REJECTION OF H-2-DEFICIENT LYMPHOMA VARIANTS SUGGESTS ALTERNATIVE IMMUNE DEFENSE STRATEGY
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DOI：
10.1038/319675a0
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发表时间：
1986-02-20
期刊：
影响因子：
64.8
通讯作者：
KIESSLING, R
中科院分区：
文献类型：
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作者：
KARRE, K;LJUNGGREN, HG;KIESSLING, R
后生动物生物不仅可以通过外来抗原的存在，而且还可以通过缺乏正常的自我标记物来区分自我和非自我。哺乳动物的获得性免疫反应使用第一种策略，另外要求在细胞表面的自身主要组织相容性复合体(MHC)产物的背景下识别外来抗原2。因此，不能充分表达MHC产物的异常细胞可以避免检测到2-4。通过对与转移和自然耐药相关的现象的重新解释，提出了一种更原始但更互补的防御系统，在缺乏自我标记的基础上消除这些细胞。我们现在表明，选择H-2表达缺失的小鼠淋巴瘤细胞在同基因宿主中低剂量接种后恶性程度低于野生型细胞，并且这种细胞的排斥反应是非适应性的。根据我们的数据，我们认为自然杀伤细胞是防御系统中的效应细胞，旨在检测自身MHC的缺失或表达减少。
Metazoan organisms may discriminate between self and non-self not only by the presence of foreign antigens but also by the absence of normal self markers1. Mammalian adaptive immune responses use the first strategy, with the additional requirement that foreign antigens are recognized in the context of self-major histocompatibility complex (MHC) products at the cell surface2. Aberrant cells which fail to express MHC products adequately can therefore avoid detection2–4. A more primitive but complementary defence system, eliminating such cells on the basis of absent self-markers, is suggested by a re-interpretation5,6of phenomena associated with metastasis and natural resistance. We now show that murine lymphoma cells selected for loss of H–2 expression are less malignant after low-dose inoculation in syngeneic hosts than are wild-type cells, and that the rejection of such cells is non-adaptive. On the basis of our data, we suggest that natural killer cells are effector cells in a defence system geared to detect the deleted or reduced expression of self-MHC.