REGULATION OF PROLIFERATION OF NORMAL AND NEOPLASTIC RAT LIVER CELLS BY CALCIUM AND CYCLIC AMP
REGULATION OF PROLIFERATION OF NORMAL AND NEOPLASTIC RAT LIVER CELLS BY CALCIUM AND CYCLIC AMP
复制标题
钙和环AMP对正常和肿瘤大鼠肝细胞增殖的调节
DOI：
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发表时间：
1980
影响因子：
5.2
通讯作者：
P. Walker
中科院分区：
文献类型：
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作者：
S. Swierenga;J. Whitfield;A. Boynton;J. Macmanus;R. Rixon;M. Sikorska;B. Tsang;P. Walker
钙离子和环磷酸腺苷控制非致瘤性肝细胞的增殖。这些试剂似乎是开始合成脱氧核糖核苷酸（最早的DNA合成过程）的信号的共同发生器。相反，钙对体外致瘤细胞的增殖几乎没有影响。一些可能的原因，这种失控，并讨论了有用的这个属性作为检测致癌物质的工具。
Calcium and cyclic AMP control the proliferation of nontumorigenic liver cells. These agents seem to be cogenerators of a signal to start synthesizing deoxyribonucleotides, the earliest of the DNA synthetic processes. By contrast, calcium has little or no effect on the proliferation of tumorigenic cells in vitro. Some possible reasons for this loss of control are presented, and the usefulness of this property as a tool for the detection of carcinogens is discussed.