Tricyclic antidepressant use and the risk of fibrosis progression in hepatitis C-infected persons: Results from ERCHIVES.
Tricyclic antidepressant use and the risk of fibrosis progression in hepatitis C-infected persons: Results from ERCHIVES.
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DOI：
10.1111/jvh.12884
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发表时间：
2018-07
影响因子：
2.5
通讯作者：
Butt AA
中科院分区：
文献类型：
--
作者：
Chen JY;Ren Y;Yan P;Belina ME;Chung RT;Butt AA
最近的临床前研究表明三环类抗抑郁药具有抗纤维化作用。使用电子检索队列HCV感染的退伍军人，我们的目的是评估TCA的使用对纤维化进展和HCV感染者肝细胞癌（HCC）的发展的影响。受试者根据使用三环类抗抑郁药、选择性5-羟色胺再摄取抑制剂或未使用抗抑郁药进行分类。三环类抗抑郁药或选择性5-羟色胺摄取抑制剂的使用根据累积限定日剂量来定义，并且类别相互排斥。基线时合并HIV感染、HBsAg阳性、肝硬化或HCC的受试者被排除。结果是通过APRI评分测量的肝纤维化进展和HCC事件。我们利用考克斯比例风险回归来确定肝硬化的预测因子，定义为APRI > 2和iHCC。在128，201名合格的HCV+患者中，4%接受了三环类抗抑郁药，43%接受了选择性5-羟色胺摄取抑制剂，53%没有接受抗抑郁药。与选择性5-羟色胺摄取抑制剂使用者相比，三环类抗抑郁药使用者有药物滥用（34%和43%）和酒精滥用（32%和42%）。校正年龄、基线APRI评分、糖尿病、高血压、饮酒、药物滥用和HCV RNA水平后，三环类抗抑郁药的使用与肝硬化风险降低（风险比[HR] = 0.77，95% CI = 0.60，0.99）和肝硬化发生时间延迟相关，但与iHCC减少无关。总之，在HCV阳性退伍军人的大队列中，三环类抗抑郁药的使用与纤维化进展减少和肝硬化风险降低相关。这些数据为三环类抗抑郁药对慢性HCV感染患者肝纤维化进展的有益作用提供了支持性证据。
Recent preclinical studies have suggested an antifibrotic role for tricyclic antidepressants. Using the Electronically Retrieved Cohort of HCV Infected Veterans, we aimed to evaluate the impact of TCA use on fibrosis progression and development of hepatocellular carcinoma (HCC) among HCV-infected persons. Subjects were categorized according to use of tricyclic antidepressants, selective serotonin reuptake inhibitors, or no antidepressants. tricyclic antidepressants or selective serotonin uptake inhibitors use was defined according to cumulative defined daily dose, and categories were mutually exclusive. Subjects with HIV coinfection, HbsAg positivity, cirrhosis, or HCC at baseline were excluded. Outcomes were liver fibrosis progression measured by APRI scores and incident HCC. We utilized Cox proportional hazards regression to determine predictors of cirrhosis, defined as APRI > 2, and iHCC. Among 128,201 eligible HCV+ persons, 4% received tricyclic antidepressants, 43% received selective serotonin uptake inhibitors, and 53% received no antidepressants. Fewer tricyclic antidepressants users had drug abuse (34% and 43%) and alcohol abuse (32% vs 42%) compared to selective serotonin uptake inhibitor users. After adjusting for age, baseline APRI score, diabetes, hypertension, alcohol use, drug abuse, and HCV RNA levels, tricyclic antidepressants use was associated with decreased risk of cirrhosis (hazard ratio [HR] = 0.77, 95% CI = 0.60, 0.99) and delayed time to development of cirrhosis, but not with decreased iHCC. In conclusion among a large cohort of HCV-positive Veterans, tricyclic antidepressants use was associated with decreased fibrosis progression and lower risk of developing cirrhosis. These data provide supportive evidence for the beneficial effects of tricyclic antidepressants on progression of liver fibrosis in patients with chronic HCV infection.
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影响因子：
--
作者：
Chen VC;Lin CF;Hsieh YH;Liang HY;Huang KY;Chiu WC;Lee Y;McIntyre RS;Chan HL
通讯作者：
Chan HL
影响因子：
4.6
作者：
Chen JY;Newcomb B;Zhou C;Pondick JV;Ghoshal S;York SR;Motola DL;Coant N;Yi JK;Mao C;Tanabe KK;Bronova I;Berdyshev EV;Fuchs BC;Hannun Y;Chung RT;Mullen AC
通讯作者：
Mullen AC
影响因子：
25.7
作者：
Fucho, Raquel;Martinez, Laura;Baulies, Anna;Torres, Sandra;Tarrats, Nuria;Fernandez, Anna;Ribas, Vicente;Astudillo, Alma M.;Balsinde, Jesus;Garcia-Roves, Pablo;Elena, Montserrat;Bergheim, Ina;Lotersztajn, Sophie;Trautwein, Christian;Appelqvist, Hanna;Paton, Adrienne W.;Paton, James C.;Czaja, Mark J.;Kaplowitz, Neil;Fernandez-Checa, Jose C.;Garcia-Ruiz, Carmen
通讯作者：
Garcia-Ruiz, Carmen
DOI：
10.1086/599371
发表时间：
2009-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Butt AA;Xiaoqiang W;Budoff M;Leaf D;Kuller LH;Justice AC
通讯作者：
Justice AC
影响因子：
13.5
作者：
George, Sarah L.;Bacon, Bruce R.;Brunt, Elizabeth M.;Mihindukulasuriya, Kusal L.;Hoffmann, Joyce;Di Bisceglie, Adrian M.
通讯作者：
Di Bisceglie, Adrian M.