Effect of chest x-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the International BRCA1/2 Carrier Cohort Study:: A report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group
Effect of chest x-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the International BRCA1/2 Carrier Cohort Study:: A report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group
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DOI：
10.1200/jco.2005.03.3126
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发表时间：
2006-07-20
影响因子：
45.3
通讯作者：
Goldgar, David E.
中科院分区：
文献类型：
--
作者：
Andrieu, Nadine;Easton, Douglas F.;Goldgar, David E.
目的携带BRCA 1和BRCA 2基因生殖系突变的妇女患乳腺癌（BC）的风险大大增加。许多研究表明，中等到高剂量的电离辐射是BC的危险因素。由于DNA修复中的BBCA蛋白的作用，我们假设BRCA载体可能是更敏感的电离辐射比妇女在一般population.Patients和MethodsA回顾性队列研究的1,601女性BRCA 1/2载体进行。乳腺癌的风险暴露于胸部X射线，通过问卷调查数据进行评估，进行了分析，使用加权考克斯比例风险model.ResultsIn这个队列，任何报告的胸部X射线暴露与BC的风险增加（风险比[HR]-1.54，P = 0.007）。40岁及以下携带者的风险增加（HR = 1.97-1 P
PurposeWomen who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing radiation are a risk factor for BC. Because of the role of the BBCA proteins in DNA repair, we hypothesized that BRCA carriers might be more sensitive to ionizing radiation than women in the general population.Patients and MethodsA retrospective cohort study of 1,601 female BRCA1/2 carriers was performed. Risk of breast cancer from exposure to chest x-rays, as assessed by questionnaire data, was analyzed using a weighted Cox proportional hazards model.ResultsIn this cohort, any reported exposure to chest x-rays was associated with an increased risk of BC (hazard ratio [HR] - 1.54; P =.007). This risk was increased in carrier women aged 40 years and younger (HR = 1.97-1 P