[Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome].
[Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome].
复制标题
中国阻塞性睡眠呼吸暂停综合征患者血管紧张素Ⅰ转换酶基因多态性研究
DOI：
--
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
C. Qiu
中科院分区：
文献类型：
--
作者：
Y. Xiao;X. Huang;C. Qiu
客观的
OBJECTIVE
To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS).
METHOD
Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers were flanking the polymorphic region in intron 16 of the ACE gene.
RESULT
The distribution of the DD, ID, and II ACE genotypes was 16%, 52%, and 32% in the control subjects and 0%, 56%, and 44% in OSAS patients, respectively. The estimated frequencies of the insertion allele and the deletion allele were 58%, 42% in the control subjects and 72%, 28% in OSAS patients, respectively. The differences were statistically significant(P < 0.05). The OSAS patients with I/I genotype had significantly longer apnea time (P < 0.05), lower minimum SaO2(P < 0.05) and more severe AHI (P < 0.05) than did the OSAS patients with I/D genotype.
CONCLUSION
These results indicate that the II genotype and I allele might be a risk factor for OSAS in Chinese.