Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees
Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees
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DOI：
10.1093/rheumatology/keq034
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发表时间：
2010-05-01
期刊：
影响因子：
5.5
通讯作者：
Cicuttini, Flavia M.
中科院分区：
文献类型：
--
作者：
Wang, Yuanyuan;Wluka, Anita;Cicuttini, Flavia M.
目标。患有 OA 的膝盖通常会出现半月板挤压，并且与软骨变化有关。目前尚不清楚半月板挤压是否与软骨下骨有关。本研究的目的是检查半月板挤压与膝关节软骨和软骨下骨之间的关系，以及轻度至中度膝关节骨关节炎队列中这些结构在 2 年内的变化。方法。 117 名患有膝关节骨关节炎的受试者参加了这项研究，并在基线时和两年后的情况下对有症状的膝关节进行了 MRI 检查。在基线时评估半月板挤压；在基线和随访时测量胫骨软骨体积和平台骨面积、软骨下骨髓病变（BML）和骨囊肿。结果。在基线时，半月板挤压与胫骨软骨体积减少、胫骨平台面积增加、内侧和外侧胫股骨间室 BML 和骨囊肿患病率增加相关（所有 P
Objectives. Meniscal extrusion is often present in knees with OA, and has been associated with cartilage changes. It is unknown whether meniscal extrusion is related to subchondral bone. The aim of the study was to examine the relationship between meniscal extrusion and knee cartilage and subchondral bone, and also changes in these structures over 2 years in a cohort with mild to moderate knee OA.Methods. One hundred and seventeen subjects with knee OA entered the study and underwent MRI on their symptomatic knee at baseline and similar to 2 years later. Meniscal extrusion was assessed at baseline; tibial cartilage volume and plateau bone area, subchondral bone marrow lesions (BMLs) and bone cysts were measured at baseline and follow-up.Results. At baseline, meniscal extrusion was associated with reduced tibial cartilage volume, increased tibial plateau area, increased prevalence of BMLs and bone cysts in both medial and lateral tibiofemoral compartments (all P