The basophil adenomas of the pituitary body.
The basophil adenomas of the pituitary body.
复制标题
垂体嗜碱性粒细胞腺瘤。
DOI：
10.1097/00005053-193207000-00005
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发表时间：
1932
影响因子：
1.4
通讯作者：
H. Cushing
中科院分区：
文献类型：
--
作者：
H. Cushing
导论.在1912年出版的一本关于垂体体及其疾病的早已被取代的专著中，有一节专门讨论了一组表现出特殊的多腺综合征的病例。当时有人说，“多腺体综合征”一词只不过意味着，当其中一个腺体的活动受到主要影响时，无导管腺体系列中就会发生继发性功能改变;此外，这个术语仅限于那些难以判断最初故障所在的病例。垂体的原发性紊乱，无论是自发发生的还是实验诱导的，都特别容易引起其他内分泌器官的广泛变化，即使在早期，人们也认识到了这一点，并且强烈怀疑这个位于中心并受到良好保护的结构很可能代表了内分泌系统的主腺。肢端肥大症的多腺体增生，在甲状腺和肾上腺皮质中表现得如此明显，这是众所周知的，而垂体功能不全的相反状态所引起的这些腺体中同样显著的萎缩性改变，也逐渐得到同样充分的认识。但是，尽管有这些充满希望的迹象，我们仍然在盲目地探索许多其他疾病的解释，这些疾病显然是由内分泌引起的，如与松果体、甲状旁腺或肾上腺肿瘤有关的疾病。在这种朦胧中，那些对这一主题真正感兴趣的人，一步一步地摸索着前进，尽管有无数的陷阱和绊脚石。
Introduction. In a long since superseded monograph on the pituitary body and its disorders, published in 1912, a section was devoted to a group of cases which showed peculiar and sundry polyglandular syndromes. It was stated at the time that the term "polyglandular syndrome" implied nothing more than that secondary functional alterations occur in the ductless-gland series whenever the activity of one of the glands becomes primarily affected; and further, that the term, as employed, was restricted to those cases in which it was difficult to tell where the initial fault lay. That a primary derangement of the pituitary gland, whether occurring spontaneously or experimentally induced, was particularly prone to cause widespread changes in other endocrine organs was appreciated even at that early day, and it was strongly suspected that this centrally placed and well protected structure in all probability represented the master-gland of the endocrine series. The multiglandular hyperplasias of acromegaly, so evident in the thyroid gland and adrenal cortex, were already known, and the no less striking atrophic alterations in these same glands brought about by the counter state of pituitary insufficiency were coming to be equally well recognized. But in spite of these hopeful signs, we were still groping blindly for an explanation of many other disorders, obviously of endocrine origin, like those associated with pineal, parathyroid or suprarenal tumors. Out of this obscurity, those seriously interested in the subject have, step by step, been feeling their way in spite of pitfalls and stumbling blocks innumerable.