Spatial segregation of excitatory and inhibitory effects of 5-HT on crayfish motoneurons.
Spatial segregation of excitatory and inhibitory effects of 5-HT on crayfish motoneurons.
复制标题
5-HT 对小龙虾运动神经元的兴奋和抑制作用的空间分离。
DOI：
--
复制
发表时间：
2013
影响因子：
2.5
通讯作者：
D. Cattaert
中科院分区：
文献类型：
--
作者：
Julien Bacqué;Fadi A. Issa;D. H. Edwards;D. Cattaert
Altering neuronal membrane properties, including input resistance, is a key modulatory mechanism for changing neural activity patterns. The effect of membrane currents generated by either synaptic or voltage-dependent channels directly depends on neuron input resistance. We found that local application of serotonin to different regions of identified motoneurons (MNs) of the postural/walking network of isolated crayfish produced different changes in input resistance. Puff-applied 5-HT in the periphery of the initial segment produced exclusively inhibitory responses. In contrast, when 5-HT was puff-applied on the central arbor of the same depressor (Dep) MN, exclusively depolarizing responses were obtained. Both inhibitory and excitatory responses were direct because they persisted in low-calcium saline. We found numerous close appositions between 5-HT-immunoreactive processes and the initial segment of dextran-rhodamine-filled Dep MNs. In contrast, almost no close apposition sites were found in Dep MN arbor. It seems that the 5-HT controls the level of excitability of postural network MNs by two mechanisms acting at two different sites: inhibitory responses (consistent with an action involving opening of K(+) channels) occur in the initial segment region and may involve classic synaptic transmission, whereas depolarizing responses (consistent with an action involving closing of K(+) channels) occur on MN branches via apparent paracrine effects.
DOI：
10.1073/pnas.94.11.5939
发表时间：
1997-05-27
影响因子：
11.1
作者：
Huber, R;Smith, K;Kravitz, EA
通讯作者：
Kravitz, EA
影响因子：
2.5
作者：
Lee, Sun Hee Cho;Taylor, Karen;Krasne, Franklin B.
通讯作者：
Krasne, Franklin B.