Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae)
Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae)
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DOI：
10.1073/pnas.1621224114
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发表时间：
2017-03-21
影响因子：
11.1
通讯作者：
Elleder, Daniel
中科院分区：
文献类型：
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作者：
Farkasova, Helena;Hron, Tomas;Elleder, Daniel
逆转录病毒可在渗入其宿主的生殖细胞中时产生内源形式。这些形式然后垂直传播，可以被认为是古代病毒的遗传化石。所有的逆转录病毒属，除了deltaretroviruses，已确定其代表性在宿主基因组中作为病毒化石记录。在这里，我们描述了一种内源性的德尔塔逆转录病毒，在长指蝙蝠（Miniopteridae）的生殖系中鉴定。这种逆转录病毒的一个单一的、严重缺失的拷贝已经在小翅目物种的基因组中被发现，但在遗传学上最接近的蝙蝠科（Vespertilionidae和Cistugonidae）的基因组中没有发现。因此，内源化发生在2000万至4500万年前的时间间隔内。这一发现填补了逆转录病毒化石记录中的最后一个主要空白，并为哺乳动物中的deltaretroviruses历史提供了重要见解。
Retroviruses can create endogenous forms on infiltration into the germline cells of their hosts. These forms are then vertically transmitted and can be considered as genetic fossils of ancient viruses. All retrovirus genera, with the exception of deltaretroviruses, have had their representation identified in the host genome as a virus fossil record. Here we describe an endogenous Deltaretrovirus, identified in the germline of long- fingered bats (Miniopteridae). A single, heavily deleted copy of this retrovirus has been found in the genome of miniopterid species, but not in the genomes of the phylogenetically closest bat families, Vespertilionidae and Cistugonidae. Therefore, the endogenization occurred in a time interval between 20 and 45 million years ago. This discovery closes the last major gap in the retroviral fossil record and provides important insights into the history of deltaretroviruses in mammals.