Clinical utility of the normal database of 123I-iodoamphetamine brain perfusion single photon emission computed tomography for statistical analysis using computed tomography-based attenuation correction: a multicenter study
Clinical utility of the normal database of 123I-iodoamphetamine brain perfusion single photon emission computed tomography for statistical analysis using computed tomography-based attenuation correction: a multicenter study
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123I-碘苯丙胺脑灌注单光子发射计算机断层扫描正常数据库的临床效用，使用基于计算机断层扫描的衰减校正进行统计分析：一项多中心研究
作者：
Takahiro Yamazaki;Yoshitaka Inui;T. Ichihara;Masaki Uno;S. Ota;A. Toyoda;Masanobu Ishiguro;Takashi Kato;Kengo Ito;H. Toyama
我们建立了一个适用于多中心环境的通用正态数据库（NDB），用于脑灌注单光子发射计算机断层扫描（SPECT）的三能量窗散射校正、基于计算机断层扫描的衰减校正（CTAC）和空间分辨率补偿的统计分析。本研究旨在比较CTAC正常数据库（CTAC- ndb）与常规正常数据库对三家机构123i -碘安非他明（123I-IMP）脑灌注SPECT的统计分析，并评估CTAC- ndb的临床疗效。我们招募了来自三家机构的45例阿尔茨海默病（AD, n = 26）、路易体痴呆（DLB, n = 9）和轻度认知障碍（n = 10）患者（男性26例，女性19例，平均年龄74.2±3.9岁，精神状态检查评分19.8±6.1）。采用三维立体定向表面投影（3D-SSP）技术对123I-IMP脑灌注SPECT图像数据进行分析，并与CTAC-NDB和常规NDB进行比较。我们目视评估每个3D-SSP z评分图，以确定特定发现的变化，如AD/DLB模式。此外，采用立体定向提取估计分析软件测量区域z评分的严重程度，作为半定量评价。在视觉评估中，所有病例在顶叶联合皮层、颞下皮质、额叶皮质和枕侧皮质中，CTAC-NDB比常规NDB显示出更清晰的结果。相反，大脑内侧区域（包括楔前叶和后扣带）的结果在71%的病例中变得模糊，在25%的病例中保持不变。在半定量分析中，在研究中包括的三个机构的平均z分数中观察到类似的趋势。使用CTAC-NDB，头盖骨附近的发现变得越来越清晰，而大脑内侧表面的发现变得不那么明确或保持不变。这些发现通过半定量分析得到证实。此外，在这三个机构中也观察到类似的减少模式变化。因此，具有CTAC的新数据库可能适用于其他机构。本研究收集的数据可作为CTAC-NDB。
We have established a common normal database (NDB) with applicability in multicenter settings for the statistical analysis of brain perfusion single photon emission computed tomography (SPECT) with triple energy window scatter correction, computed tomography-based attenuation correction (CTAC), and spatial resolution compensation. This study aimed to compare the CTAC normal database (CTAC-NDB) with conventional normal databases for the statistical analysis of 123I-iodoamphetamine (123I-IMP) brain perfusion SPECT at three institutions and to assess the clinical efficiency of CTAC-NDB. We recruited 45 patients (26 men and 19 women; mean age, 74.2 ± 3.9 years; Mini-Mental State Examination score, 19.8 ± 6.1) with Alzheimer’s disease (AD, n = 26), dementia with Lewy bodies (DLB, n = 9), and mild cognitive impairment (n = 10) from three institutions. Three-dimensional stereotactic surface projection (3D-SSP) technique was used to analyze data obtained from the 123I-IMP brain perfusion SPECT images compared with both CTAC-NDB and conventional NDB. We visually assessed each 3D-SSP z score map to determine the changes in specific findings, such as AD/DLB pattern. Furthermore, the stereotactic extraction estimation analysis software was used to measure the regional z score severity and extent as a semiquantitative assessment. In the visual assessment, all cases exhibited clearer findings with CTAC-NDB than with conventional NDB in the parietotemporal association cortex as well as in the inferior temporal, frontal, and lateral occipital cortices. Contrarily, the findings from the medial cerebral regions, including the precuneus and the posterior cingulate, became indistinct in 71% of the cases and remained unchanged in 25% of the cases. In the semiquantitative analysis, a similar tendency was observed in the mean z score in the three institutions included in the study. Using the CTAC-NDB, the findings in the vicinity of the cranium became increasingly clear, whereas those in the medial surface of the brain became less defined or remained unchanged. These findings were confirmed via a semiquantitative analysis. Moreover, similar changes in the reduction pattern were observed in the three institutions. Therefore, the new database with CTAC might be applicable in other institutions. Data collected in this study may serve as a CTAC-NDB.
DOI：
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发表时间：
1995-07
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
S. Minoshima;K. Frey;K. Frey;R. Koeppe;N. Foster;David E. Kuhl
通讯作者：
S. Minoshima;K. Frey;K. Frey;R. Koeppe;N. Foster;David E. Kuhl