Malignant neoplasms in rats fed lasiocarpine.
Malignant neoplasms in rats fed lasiocarpine.
复制标题
喂食毛果芸香碱的大鼠体内的恶性肿瘤。
作者：
M. Rao;J. Reddy
20只雄性F-344大鼠以50/10（6）的饮食浓度喂食Lasiocarpine（一种吡咯里西啶生物碱）55周。在48至59周之间，20只动物中有17只发生恶性肿瘤。45%（9/20）发生肝血管瘤，35%（7/20）发生肝细胞癌。其他肿瘤包括皮肤恶性附件肿瘤（1只大鼠）和卵巢癌（1只大鼠）。在4只肝脏血管肉瘤动物和1只肝细胞癌动物中观察到肺转移。从一只动物，血管肉瘤移植成功，通过4代。
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.