CHOLINERGIC PROJECTIONS FROM THE BASAL FOREBRAIN TO FRONTAL, PARIETAL, TEMPORAL, OCCIPITAL, AND CINGULATE CORTICES - A COMBINED FLUORESCENT TRACER AND ACETYLCHOLINESTERASE ANALYSIS
CHOLINERGIC PROJECTIONS FROM THE BASAL FOREBRAIN TO FRONTAL, PARIETAL, TEMPORAL, OCCIPITAL, AND CINGULATE CORTICES - A COMBINED FLUORESCENT TRACER AND ACETYLCHOLINESTERASE ANALYSIS
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DOI：
10.1016/0361-9230(82)90101-0
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发表时间：
1982-01-01
影响因子：
3.8
通讯作者：
BUTCHER, LL
中科院分区：
文献类型：
--
作者：
BIGL, V;WOOLF, NJ;BUTCHER, LL
本研究采用荧光示踪组织学结合乙酰胆碱酯酶（AChE）药物组织化学方法，对大鼠基底前脑胆碱能神经元的形态、细胞间结构和皮质投射模式进行了观察。强染色AChE细胞投射到额叶感觉运动（区10），顶叶（区2）和颞叶（区41）皮质被发现同侧在视前核magnocellularis，在基底核和associationm与实质性无名，袢和外侧下丘脑区;一个基本上rostrocaudal地形观察这些预测。含乙酰胆碱酯酶的途径扣带回（区29）和视觉（区17）皮层来自同侧的躯体与垂直和水平的四肢的斜角带，核preopticus magnocellularis，吻侧部分的基底核和无名质。神经元支配区29一般位于更rostrally比那些引起AChE传入区17。大多数细胞似乎支配皮质相对离散的区域。证据collaterialization只在神经元投射到视觉和扣带皮层，这些代表只有3.2%的细胞提供乙酰胆碱酯酶传入区17和29。基底前脑AChE投射细胞通常较大（最大细胞体范围> 25 μ m），并且它们的胞体主要是椭圆形的，具有较小比例的梭形或三角形。许多组织成簇，特别是在基底核。
The morphologies, intercellular organization and cortical projection patterns of putative cholinergic neurons in the basal forebrain of the rat were examined by use of fluorescent tracer histology in combination with the pharmacohistochemical regimen for acetylcholinesterase (AChE). Intensely staining AChE-containing cells projecting to frontal sensorimotor (Area 10), parietal (Area 2) and temporal (Area 41) cortices were found ipsilaterally in nucleus preopticus magnocellularis, in nucleus basalis and in associationm with the substantial innominata, the ansa lenticularis and the lateral hypothalamic area; an essentially rostrocaudal topography was observed for these projections. AChE-containing pathways to cingulate (Area 29) and visual (Area 17) cortices derived from ipsilateral somata associated with the vertical and horizontal limbs of the diagonal band, nucleus preopticus magnocellularis, rostral portions of nucleus basalis and the substantia innominata. Neurons innervating Area 29 were generally located more rostrally than those giving rise to AChE afferents to Area 17. The majority of cells appeared to innervate relatively discrete areas of the cortex. Evidence for collaterialization was found only in neurons projecting to visual and cingulate cortices; these represented only 3.2% of the cells providing AChE afferents to Areas 17 and 29. The basal forebrain AChE projection cells were typically large (> 25 .mu.m in maximum cell body extent), and their somata were predominantly oval, with lesser proportions being fusiform or triangular. Many were organized in clusters, particularly in nucleus basalis.