TRANSCRIPTIONAL INDUCTION OF 2 GENES IN HUMAN-CELLS BY BETA-INTERFERON
TRANSCRIPTIONAL INDUCTION OF 2 GENES IN HUMAN-CELLS BY BETA-INTERFERON
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DOI：
10.1073/pnas.81.21.6733
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
DARNELL, JE
中科院分区：
文献类型：
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作者：
LARNER, AC;JONAK, G;DARNELL, JE
干扰素与不同细胞表面受体的结合会诱导几种独特多肽及其相应 mRNA 的合成 (1-6)。分离出与核RNA互补的两种c[互补]DNA，其合成在添加β后30-60分钟内从不可检测的水平诱导至最大转录率。干扰素对人成纤维细胞或 HeLa 细胞的影响。单个多肽可以通过与特定的质膜受体结合，迅速激活一组确定的基因的转录。
The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNA (1-6). Two c[complementary]DNA were isolated that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of .beta. interferon to human fibroblasts or to HeLa cells. A single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes.