Do cognitive deficits predict negative emotionality and aggression in schizophrenia?
Do cognitive deficits predict negative emotionality and aggression in schizophrenia?
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DOI：
10.1016/j.psychres.2017.11.003
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发表时间：
2018-01-01
影响因子：
11.3
通讯作者：
Lindenmayer, Jean-Pierre
中科院分区：
文献类型：
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作者：
Ahmed, Anthony O.;Richardson, Jenae;Lindenmayer, Jean-Pierre
精神分裂症与攻击性风险升高有关。认知缺陷与住院攻击和未来暴力有关。然而，认知缺陷和暴力行为之间的关系在不同的研究中并不一致。此外，研究未能告知认知缺陷如何导致精神分裂症的攻击性。目前的研究探讨了认知缺陷与精神分裂症相关的侵略和暴力犯罪的关联。本研究还探讨了负性情绪在认知缺陷对攻击性影响中的中介作用。精神分裂症和情感性精神障碍患者（N = 78）从州立医院招募。参与者根据他们的暴力犯罪史进行分类。参与者完成了认知，症状和攻击性的测量。工作记忆，推理/解决问题和口头学习的缺陷是最优先的预测暴力罪犯的地位。暴力犯罪者在大多数认知领域表现出更大的障碍，特别是工作记忆和语言学习。罪犯也表现出更大的负面情绪，兴奋/激动，以及言语和身体攻击的事件。在冥想模型中，负性情绪和兴奋/激动完全传递了认知缺陷对冲动性攻击的影响。认知缺陷通过对负性情感状态的无效调节增加精神分裂症患者冲动性攻击的风险。
Schizophrenia is associated with an elevated risk of aggression. Cognitive deficits have been associated with inpatient aggression and future violence. The relationship between cognitive deficits and violent behavior has however been inconsistent across studies. In addition, studies have failed to inform how cognitive deficits may contribute to aggression in schizophrenia. The current study examined the association of cognitive deficits with schizophrenia-related aggression and violent offending. It also explored the putative mediating role of negative emotionality on the impact of cognitive deficits on aggression. People with schizophrenia and schizoaffective disorder (N = 78) were recruited from a state hospital. Participants were classified based on their history of violent offending. Participants completed measures of cognition, symptoms, and aggression. Deficits in working memory, reasoning/problem-solving, and verbal learning were the most prioritized for the prediction of violent offender status. Violent offenders demonstrated greater impairments in most cognitive domains especially working memory and verbal learning. Offenders also demonstrated greater negative emotionality, excitement/agitation, and incidents of verbal and physical aggression. Negative emotionality and excitement/agitation fully transmitted the effect of cognitive deficits on impulsive aggression in meditational models. Cognitive deficits increase the risk of impulsive aggression in schizophrenia via inefficient regulation of negative affective states.