Effects of the FABP2 A54T mutation on triglyceride metabolism of viscerally obese men
Effects of the FABP2 A54T mutation on triglyceride metabolism of viscerally obese men
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DOI：
10.1038/oby.2001.91
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发表时间：
2001-11-01
期刊：
影响因子：
--
通讯作者：
Vohl, MC
中科院分区：
文献类型：
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作者：
Berthier, MT;Couillard, C;Vohl, MC
目的：内脏性肥胖者常伴有致动脉粥样硬化性疾病。脂肪酸结合蛋白2（FABP 2）基因中的错义突变（A54 T）与胰岛素抵抗和肥胖相关。本研究探讨了这种突变对脂蛋白水平内脏肥胖hyperinsulinemic condition.Research Methods和Procedures的影响：共217名男子被分配到两个组之一，根据他们的FABP 2 A54 T polymorphism.Results：两个基因型组显示没有差异，无论是生理特征或脂蛋白/血脂谱，统计调整年龄之前或之后。从这个初始样本中，50名男性接受餐后脂质反应评估，然后将10名T54/A54杂合子与10名A54/A54纯合子的内脏脂肪组织积累和空腹血浆甘油三酯（TG）水平单独匹配。在携带A54 T突变的男性中，高密度脂蛋白（HDL）TG水平在空腹状态以及试验餐后4小时显著升高（分别为p = 0.04和p = 0.0008）。此外，T54/A54杂合子的餐后HDL-TG水平曲线下面积也显著高于A54/A54纯合子（p = 0.04）。有趣的是，富含TG的大脂蛋白中的空腹TG浓度（大TRL; S-f > 400）与HDL-TG水平相关，（r = 0.74，p = 0.01）和8小时（r = 0.73，p = 0.01）仅在T54/A54杂合子中试验餐后。FABP 2 A54 T错义突变可能导致餐后状态下HDL的TG富集，进而可能改变动脉粥样硬化性血管疾病的风险。
Objective: Viscerally obese individuals are frequently characterized by a proatherogenic condition. A missense mutation (A54T) in the fatty acid binding protein type 2 (FABP2) gene has been associated with insulin resistance and obesity. This study examined the effect of this mutation on lipoprotein levels in viscerally obese hyperinsulinemic condition.Research Methods and Procedures: A total of 217 men were assigned to one of two groups based on their FABP2 A54T polymorphism.Results: The two genotypic groups showed no difference in either physiological characteristics or lipoprotein/lipid profile, before or after statistical adjustment for age. From this initial sample, 50 men accepted to have their postprandial lipid response assessed and 10 T54/A54 heterozygotes were then individually matched for visceral adipose tissue accumulation and fasting plasma triglyceride (TG) levels with 10 A54/A54 homozygotes. high-density lipoprotein (HDL)TG levels were significantly increased in the fasting state as well as 4 hours after the test meal (p = 0.04 and p = 0.0008, respectively) in men bearing the A54T mutation. In addition, the area under the curve of postprandial HDL-TG levels was also significantly higher among T54/A54 heterozygotes than among A54/A54 homozygotes (p = 0.04). Interestingly, fasting TG concentrations in large TG-rich lipoproteins (large-TRL; S-f > 400) were correlated with HDL-TG levels at 4 (r = 0.74, p = 0.01) and 8 hours (r = 0.73, p = 0.01) after the test meal in T54/A54 heterozygotes only.Discussion: The FABP2 A54T missense mutation may contribute to the TG enrichment of HDL in the postprandial state that, in turn, may alter the risk of atherosclerotic vascular disease.