Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease
Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease
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DOI：
10.1016/j.neulet.2007.02.021
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发表时间：
2007-05-01
影响因子：
2.5
通讯作者：
Tomimoto, Hidekazu
中科院分区：
文献类型：
--
作者：
Kitaguchi, Hiroshi;Ihara, Masafumi;Tomimoto, Hidekazu
据报道，阿尔茨海默病 (AD) 中存在皮质微血管的形态异常，但宾斯旺格病 (BD)（血管性痴呆的一种形式）中却没有报道。因此，我们使用改良的 Gallyas 银浸渍方法和 β 淀粉样蛋白的免疫组织化学比较了 AD 和 BD 大脑中的毛细血管床。将 8 个 AD 患者尸检大脑和 7 个 BD 患者尸检大脑与 6 个对照大脑进行比较。 AD 中的皮质微血管经常变窄和撕裂，特别是在靠近老年斑的地方。与对照大脑相比，AD 中的毛细血管密度显着降低。相比之下，BD 大脑中的毛细血管密度及其形态没有显着变化。 β淀粉样蛋白的免疫组织化学显示，仅在 AD 大脑中，血管壁和血管周围神经纤维中有大量沉积物。 AD 中皮质微血管的变化以及 BD 中皮质微血管的缺失可能表明 β 淀粉样蛋白在 AD 微血管病理学中的作用。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Morphological abnormalities of the cortical microvessels have been reported in Alzheimer's disease (AD), but not in Binswanger's disease (BD), a form of vascular dementia. Therefore, we compared the capillary beds in AD and BD brains, using a modified Gallyas silver impregnation method and immunohistochemistry for beta amyloid. Eight autopsied brains with AD and seven with BD were compared with six control brains. The cortical microvessels in AD were frequently narrowed, and torn off, especially in close proximity to the senile plaques. The capillary densities in AD were significantly decreased as compared with the control brains. In contrast, there were no significant changes in the capillary densities and their morphologies in BD brains. Immunohistochemistry for beta amyloid revealed numerous deposits in the vascular wall and perivascular neuropil exclusively in AD brains. Cortical microvascular changes in AD and their absence in BD may indicate a role of beta amyloid for the microvessel pathology in AD. (c) 2007 Elsevier Ireland Ltd. All rights reserved.