The prevalence of genital HPV and factors associated with oncogenic HPV among men having sex with men and men having sex with women and men: the HIM study.
The prevalence of genital HPV and factors associated with oncogenic HPV among men having sex with men and men having sex with women and men: the HIM study.
复制标题
DOI：
10.1097/olq.0b013e31822154f9
复制
发表时间：
2011-10
影响因子：
3.1
通讯作者：
Giuliano AR
中科院分区：
文献类型：
--
作者：
Nyitray AG;da Silva RJ;Baggio ML;Lu B;Smith D;Abrahamsen M;Papenfuss M;Quiterio M;Villa LL;Giuliano AR
生殖器人乳头瘤病毒（HPV）在男男性行为者（MSM），男男性行为者（MSWM）和男男性行为者（MSW）之间的比较研究尚未进行;然而，这种比较可能对计划预防策略（如疫苗接种）很重要。在巴西圣保罗、墨西哥库埃尔纳瓦卡和美国佛罗里达坦帕，年龄18-70岁的男性参加了一项生殖器HPV研究。根据自我报告的性行为，男性被分为MSM（n=170），MSWM（n=214）和MSW（n=3326）。对来自阴茎和阴囊的细胞进行HPV基因分型。患病率数据按国家进行了调整。使用多变量Poisson回归分析评估与生殖器HPV潜在相关的因素。生殖器HPV感染率在MSWM中通常高于MSM或MSW中的HPV基因型组，包括非致癌型（分别为51%，36%和42%）和多种类型（分别为37%，24%和29%）。在MSM和MSWM中，年龄和过去一个月的饮酒量与致癌HPV相关;然而，在MSM或MSWM中，性行为与生殖器HPV之间没有统计学显著相关性。MSWM中生殖器HPV的患病率可能高于MSW或MSM。MSW女性性伴数与生殖器HPV感染相关，而MSM和MSWM男性肛交伴数与生殖器HPV感染无关。
Comparative studies of genital human papillomavirus (HPV) among men having sex with men (MSM), men having sex with women and men (MSWM), and men having sex with women (MSW) have not been conducted; however, such comparisons may be important for planning prevention strategies like vaccination. Men, aged 18–70 years, were enrolled in a study of genital HPV in São Paulo, Brazil; Cuernavaca, Mexico; and Tampa, Florida, USA. Men were classified as MSM (n=170), MSWM (n=214) and MSW (n=3326) based on self-reported sexual behavior. Genotyping for HPV was conducted on cells from the penis and scrotum. Prevalence data were adjusted by country. Factors potentially associated with genital HPV were assessed using multivariable Poisson regression. Genital HPV prevalence was typically higher among MSWM than among MSM or MSW for groups of HPV genotypes including nononcogenic types (51%, 36%, and 42%, respectively), and multiple types (37%, 24%, and 29%, respectively). Age and alcohol consumption in the past month were associated with oncogenic HPV among both MSM and MSWM; however, there were no statistically significant associations between sexual behaviors and genital HPV among MSM or MSWM. Prevalence of genital HPV may be higher among MSWM than among MSW or MSM. Number of female sex partners was associated with genital HPV among MSW, but number of male anal sex partners was not associated with genital HPV among MSM and MSWM.