Citral a fragrance allergen and irritant
Citral a fragrance allergen and irritant
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DOI：
10.1111/j.0105-1873.2003.00144.x
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发表时间：
2003-07-01
影响因子：
5.5
通讯作者：
Basketter, DA
中科院分区：
文献类型：
--
作者：
Heydorn, S;Menné, T;Basketter, DA
柠檬是一种众所周知的接触过敏原和接触刺激性。过去的常规补丁测试可能由于可能的刺激性（IR）贴剂测试响应而受到限制。连续586例患有手动湿疹的患者经过精选的香料测试，包括柠檬酸2％石油和欧洲标准系列。 28例患者表现出呈阳性的斑块测试反应（+至+++），至少1个IR斑块测试反应，没有阳性的斑块测试反应。与IR反应（n = 82）相比，与其他香料的阳性斑块测试反应与阳性斑块测试反应之间的统计学意义相关性（n = 82）。 IR和对柠檬质反应的人之间发现的香气历史的差异并不显着。柠檬质可能是过敏原和/或刺激性，值得进一步进行更广泛的研究。
Citral is a well known contact allergen and a contact irritant. Routine patch testing in the past may have been restricted because of possible irritant (IR) patch test responses. 586 consecutive patients, with hand eczema, were patch tested with a selection of fragrances including citral 2% petrolatum and the European standard series. 28 of the patients showed a positive patch test reaction (+ to +++) to citral and 82 at least 1 IR patch test reaction and no positive patch test reaction to citral. A statistically significant association between a positive patch test reaction to citral and positive patch test reactions to other fragrances compared with IR reactions (n = 82) was established. The difference regarding fragrance history found between those with IR and positive reactions to citral was not significant. Citral could be an allergen and/or irritant, worthy of further more extensive studies.