PHAGOCYTOSIS OF THE LEGIONNAIRES-DISEASE BACTERIUM (LEGIONELLA-PNEUMOPHILA) OCCURS BY A NOVEL MECHANISM - ENGULFMENT WITHIN A PSEUDOPOD COIL
PHAGOCYTOSIS OF THE LEGIONNAIRES-DISEASE BACTERIUM (LEGIONELLA-PNEUMOPHILA) OCCURS BY A NOVEL MECHANISM - ENGULFMENT WITHIN A PSEUDOPOD COIL
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DOI：
10.1016/0092-8674(84)90070-9
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发表时间：
1984-01-01
期刊：
影响因子：
64.5
通讯作者：
HORWITZ, MA
中科院分区：
文献类型：
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作者：
HORWITZ, MA
嗜肺乳杆菌的吞噬作用是通过一种新的机制发生的。嗜肺乳杆菌是一种在人的单核巨噬细胞内增殖并导致军团病的细菌病原体。当细菌内化时，吞噬细胞伪足盘绕在细菌周围。人类单核细胞、肺泡巨噬细胞和多形核白细胞都通过这种不寻常的吞噬过程吞噬嗜肺乳杆菌，称为卷曲吞噬。这些白细胞通过这种方式吞噬活的、福尔马林灭活的、戊二醛灭活的和热灭活的嗜肺乳杆菌。在相同的实验条件下，单核细胞通过常规吞噬作用吞噬肺炎链球菌、包膜和非包膜的大肠埃希菌、铜绿假单胞菌、产碱杆菌、淋球菌和脑膜炎奈瑟菌。高效价抗L-L治疗嗜肺乳杆菌嗜肺性抗体消除了卷曲吞噬作用；这种细菌被常规吞噬作用内化。显然，嗜肺性乳杆菌的一个表面成分介导了吞噬细胞的异常反应。如果在体内详细阐述，这种成分可能是疑似由毒素介导的退伍军人病肺外表现的原因。
Phagocytosis of L. pneumophila, a bacterial pathogen that multiplies intracellularly in human mononuclear phagocytes and causes Legionnaires'' disease, occurred by a novel mechanism. A phagocyte pseudopod coiled around the bacterium as the organism was internalized. Human monocytes, alveolar macrophages and polymorphonuclear leukocytes all phagocytized L. pneumophila by this unusual process, termed coiling phagocytosis. These leukocytes phagocytized live, formalin-killed, glutaraldehyde-killed and heat-killed L. pneumophila in this way. Under the same experimental conditions, monocytes phagocytized Streptococcus pneumoniae, encapsulated and unencapsulated Escherichia coli, Pseudomonas aeruginosa, P. alcaligenes, Neisseria gonorrhoeae and Neisseria meningitidis by conventional phagocytosis. Treatment of L. pneumophila with high-titer anti-L. pneumophila antibody abolished coiling phagocytosis; such bacteria were internalized by conventional phagocytosis. Evidently, a surface component of L. pneumophila mediates the unusual response by the phagocyte. Such a component, if elaborated in vivo, might be responsible for extrapulmonary manifestations of Legionnaires'' disease suspected of being toxin-mediated.