Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene expression ensure robust spatial patterning.
Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene expression ensure robust spatial patterning.
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果蝇分割中的大小调节：基因表达局部域之间的相互作用界面确保了稳健的空间模式。
DOI：
10.1103/physrevlett.103.168102
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发表时间：
2009
影响因子：
8.6
通讯作者：
Radulescu,Ovidiu
中科院分区：
文献类型：
--
作者：
Vakulenko,Sergei;Manu;Reinitz,John;Radulescu,Ovidiu
我们提出了一种新的健壮生物模式形成机制。其机理类似于凝聚介质中的界面动力学。我们应用这种方法来研究基因网络如何控制果蝇的分割。所提出的模型是最小的，只涉及4个基因和形态梯度。我们讨论了发育基因在空间上受扭结(界面)限制的区域内表达的实验数据，并且基因相互作用方案包含弱排斥和强排斥。我们展示了如何从基因相互作用中计算扭结-扭结相互作用，以及基因相互作用方案如何确保比例的控制(大小调节)。
We propose a new mechanism for robust biological patterning. The mechanism bears analogy to interface dynamics in condensed media. We apply this method to study how gene networks control segmentation ofDrosophila. The proposed model is minimal involving only 4 genes and a morphogen gradient. We discuss experimental data for which developmental genes are expressed within domains spatially limited by kinks (interfaces) and the gene interaction scheme contains both weak and strong repulsion. We show how kink-kink interactions can be calculated from the gene interactions and how the gene interaction scheme ensures the control of proportions (size regulation).