Negishi Alkyl-Aryl Cross-Coupling Catalyzed by Rh: Efficiency of Novel Tripodal 3-Diphenylphosphino-2-(diphenylphosphino)methyl-2-methylpropyl Acetate Ligand
Negishi Alkyl-Aryl Cross-Coupling Catalyzed by Rh: Efficiency of Novel Tripodal 3-Diphenylphosphino-2-(diphenylphosphino)methyl-2-methylpropyl Acetate Ligand
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DOI：
10.1021/ol100210u
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发表时间：
2010-04-16
期刊：
影响因子：
5.2
通讯作者：
Takagi, Kentaro
中科院分区：
文献类型：
--
作者：
Ejiri, Syogo;Odo, Shunsuke;Takagi, Kentaro
3-Diphenylphosphino-2-(diphenylphoshino)methyl-2-methylpropyl乙酸酯作为Rh催化剂的有效配体，实现了含吸电子基团的芳基锌化合物与烷基亲电体之间的交叉偶联。根据Rh催化的专一性，讨论了三脚架配体和这些芳基亲核试剂的有益效果。
3-Diphenylphosphino-2-(diphenylphoshino)methyl-2-methylpropyl acetate acted as an efficient ligand for a Rh catalyst, achieving cross-coupling between arylzinc compounds bearing electron-withdrawing groups and alkyl electrophiles. The beneficial effect of the tripodal ligand and such aryl nucleophiles was discussed with regard to the specificity of the Rh catalysis.