Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue.
Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue.
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从合成万古霉素类似物的 SAR 研究中鉴定强效广谱抗生素。
DOI：
10.1016/s0960-894x(03)00243-9
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发表时间：
2003
影响因子：
2.7
通讯作者：
Ellman,JonathanA
中科院分区：
文献类型：
--
作者：
Ahrendt,KateriA;Olsen,JacobA;Wakao,Masahiro;Trias,Joaquim;Ellman,JonathanA
基于从万古霉素合成类似物文库中鉴定出的先导化合物的二聚万古霉素类似物对万古霉素耐药屎肠球菌（VRE， VanA表型）的活性比万古霉素高60倍。简化的类似物也已制备并发现对VRE保持活性并具有广谱抗生素活性。
Dimeric vancomycin analogues based on a lead compound identified from a library of synthetic analogues of vancomycin have up to 60-fold greater activity than vancomycin against vancomycin-resistant Enterococcus faecium (VRE, VanA phenotype). Simplified analogues have also been prepared and found to maintain activity against VRE and have broad-spectrum antibiotic activity.