Qualitative study: burden of menopause-associated vasomotor symptoms (VMS) and validation of PROMIS Sleep Disturbance and Sleep-Related Impairment measures for assessment of VMS impact on sleep.
Qualitative study: burden of menopause-associated vasomotor symptoms (VMS) and validation of PROMIS Sleep Disturbance and Sleep-Related Impairment measures for assessment of VMS impact on sleep.
复制标题
DOI：
10.1186/s41687-021-00289-y
复制
发表时间：
2021-04-26
影响因子：
2.7
通讯作者：
DiBenedetti D
中科院分区：
文献类型：
--
作者：
English M;Stoykova B;Slota C;Doward L;Siddiqui E;Crawford R;DiBenedetti D
我们评估了绝经相关血管紧张症状（VMS）对睡眠的影响。我们还试图建立患者报告的结果测量信息系统（PROMIS）的内容有效性的简短形式的睡眠相关损害和睡眠障碍的措施，绝经后妇女中重度VMS。在美国（德克萨斯州、伊利诺伊州）和欧盟（英国、法国）对40-64岁的中度至重度VMS（≥35/周）女性进行了横断面、面对面、定性访谈。主要结果是VMS对睡眠的影响，基于PROMIS睡眠相关损害和睡眠障碍简表的概念引出和内容效度，通过认知报告。32名女性（US：n = 16; EU：n = 16）参与研究。多数（美国：93.8%;欧盟：93.8%的人表示VMS会影响睡眠;具体来说，他们的睡眠会因出汗或过热而中断，并且难以恢复睡眠。睡眠障碍是VMS最令人烦恼的方面（美国：75%;欧盟：50%）。与VMS相关的睡眠障碍影响第二天的工作效率，情绪，关系，日常活动，注意力，社交活动和身体健康。参与者发现PROMIS睡眠指标都相关且易于回答;睡眠障碍指标被认为是最相关的。参与者在7天的回忆期内没有困难记住他们的经历，并发现反应选项是不同的。与更年期相关的VMS显著干扰睡眠和第二天的功能（例如，工作效率），支持评估VMS治疗研究中的睡眠结果评估。患有中度至重度VMS的女性发现，PROMIS睡眠相关损害和睡眠障碍简表评估了在绝经相关VMS背景下理解睡眠的重要结构。在线版本包含补充材料，可通过10.1186/s41687-021-00289-y获得。
We evaluated the impact of menopause-associated vasomotor symptoms (VMS) on sleep. We also sought to establish the content validity of Patient-Reported Outcomes Measurement Information System (PROMIS) short form Sleep-Related Impairment and Sleep Disturbance measures in postmenopausal women with moderate to severe VMS. Cross-sectional, in-person, qualitative interviews were conducted in the United States (Texas, Illinois) and European Union (UK, France) with women aged 40–64 years experiencing moderate to severe VMS (≥35/wk). Main outcomes were impact of VMS on sleep based on concept elicitation and content validity of PROMIS Sleep-Related Impairment and Sleep Disturbance short forms via cognitive debriefing. Thirty-two women (US: n = 16; EU: n = 16) participated. A majority (US: 93.8%; EU: 93.8%) said VMS affected sleep; specifically, they had sleep interrupted by sweating or overheating and had difficulty returning to sleep. Sleep disturbance was the most bothersome aspect of VMS (US: 75%; EU: 50%). VMS-associated sleep disturbance affected next-day work productivity, mood, relationships, daily activities, concentration, social activities, and physical health. Participants found both PROMIS sleep measures relevant and easy to answer; the Sleep Disturbance measure was considered the most relevant. Participants had no difficulty remembering their experiences over the 7-day recall period and found the response options to be distinct. VMS associated with menopause significantly interferes with sleep and next-day functioning (e.g., work productivity), supporting assessment of sleep outcomes in studies evaluating treatment of VMS. Women with moderate to severe VMS found that the PROMIS Sleep-Related Impairment and Sleep Disturbance short forms assessed constructs important to understanding sleep in the context of menopause-associated VMS. The online version contains supplementary material available at 10.1186/s41687-021-00289-y.