BODY ENERGY STATUS AND THE METABOLIC RESPONSE TO ACUTE-INFLAMMATION
BODY ENERGY STATUS AND THE METABOLIC RESPONSE TO ACUTE-INFLAMMATION
复制标题
DOI：
10.1152/ajpregu.1995.269.5.r1024
复制
发表时间：
1995-11-01
影响因子：
2.8
通讯作者：
KEESEY, RE
中科院分区：
文献类型：
--
作者：
LENNIE, TA;MCCARTHY, DO;KEESEY, RE
使用急性炎症动物模型来研究身体能量状态如何影响厌食症、负氮平衡和通常因受伤而出现的体重减轻综合征。具体来说，在正常、升高或降低体重的大鼠中研究了对急性炎症的代谢反应。与正常体重的大鼠相比，在炎症发生前诱导过量饮食和体重增加的大鼠表现出长期厌食、随后体重减轻更大、代谢率更高以及负能量平衡更大。相反，体重减轻的大鼠表现出食物摄入量增加、体重增加、氮损失减少和能量消耗率正常。先前的体重减轻不会影响炎症后发热或纤维蛋白原、铁和白细胞介素6样活性的水平，这表明体重减轻的大鼠发起急性期反应的能力并未受到损害。这些结果表明，身体能量通量和身体氮的常见炎症后调整是对急性炎症的代谢反应的调节组成部分，这使得通常受保护的内源性能量和底物来源可用于修复和恢复。
An animal model of acute inflammation was used to examine how body energy status influences the syndrome of anorexia, negative nitrogen balance, and body weight loss typically seen in response to injury. Specifically, the metabolic response to acute inflammation was studied in rats of normal, elevated, or reduced body weights. Rats induced to overeat and gain weight prior to inflammation displayed protracted anorexia, greater subsequent weight loss, higher metabolic rates, and greater negative energy balance than rats of normal weight. Conversely, rats with reduced body weights displayed elevated food intakes, body weight gain, attenuated nitrogen loss, and normal rates of energy expenditure. Prior weight reduction did not affect postinflammation fever or levels of fibrinogen, iron, and interleukin-6-like activity, suggesting that the ability to mount an acute phase response was not impaired in weight-reduced rats. These results suggest that the usual postinflammation adjustments in body energy flux and body nitrogen are regulated components of a metabolic response to acute inflammation which renders normally protected sources of endogenous energy and substrate available for repair and recovery.